ArticleNature nanotechnology2017
Collective helicity switching of a DNA-coat assembly.
Article in Nature nanotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 116 citations in OpenAlex.
- Nontoxic mRNA vehicles based on electrically neutral self-assembling peptides.Nature communications · 2026Article
- A hydroxyl group dictates handedness, pitch, and mechanics in a crystalline covalent helical polymer.Science advances · 2025Article
- Chirality Evolution of Supramolecular Helices by Electron Transfer Assisted Secondary Nucleation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Pathway-directed recyclable chirality inversion of coordinated supramolecular polymers.Nature communications · 2024Article
- Stereospecific supramolecular polymerization of nanoclusters into ultra-long helical chains and enantiomer separation.Nature communications · 2024Article
- Reversible chirality inversion of an AuAgNature communications · 2024Article
- Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery.Nature communications · 2023Article
- Magnetic control of self-assembly and disassembly in organic materials.Nature communications · 2023Article
- Supramolecular fibrillation of peptide amphiphiles induces environmental responses in aqueous droplets.Nature communications · 2021Article
- Exploiting Coordination Isomerism for Controlled Self-Assembly.Angewandte Chemie (International ed. in English) · 2019Article
- Mechanistic Insights into the Self-Assembly of an Acid-Sensitive Photoresponsive Supramolecular Polymer.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Praseodymium promotes B-Z transition in self-assembled DNA nanostructures.RSC advances · 2019Article
- Chiral nanostructures self-assembled from nitrocinnamic amide amphiphiles: substituent and solvent effects.Beilstein journal of nanotechnology · 2019Article
- Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hierarchical assemblies of biomolecular subunits can carry out versatile tasks at the cellular level with remarkable spatial and temporal precision. As an example, the collective motion and mutual cooperation between complex protein machines mediate essential functions for life, such as replication, synthesis, degradation, repair and transport. Nucleic acid molecules are far less dynamic than proteins and need to bind to specific proteins to form hierarchical structures. The simplest example of these nucleic acid-based structures is provided by a rod-shaped tobacco mosaic virus, which consists of genetic material surrounded by coat proteins. Inspired by the complexity and hierarchical assembly of viruses, a great deal of effort has been devoted to design similarly constructed artificial viruses. However, such a wrapping approach makes nucleic acid dynamics insensitive to environmental changes. This limitation generally restricts, for example, the amplification of the conformational dynamics between the right-handed B form to the left-handed Z form of double-stranded deoxyribonucleic acid (DNA). Here we report a virus-like hierarchical assembly in which the native DNA and a synthetic coat undergo repeated collective helicity switching triggered by pH change under physiological conditions. We also show that this collective helicity inversion occurs during translocation of the DNA-coat assembly into intracellular compartments. Translating DNA conformational dynamics into a higher level of hierarchical dynamics may provide an approach to create DNA-based nanomachines.
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