Evidence map›Paper›PMID 28346443›Full record

SynthesisNature genetics2017

Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.

Beatrice S Melin, Jill S Barnholtz-Sloan, Margaret R Wrensch, Christoffer Johansen, Dora Il'yasova, Ben Kinnersley, Quinn T Ostrom, Karim Labreche, Yanwen Chen, Georgina Armstrong and 54 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 232 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
232citing papers in PubMed, 13 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

232 citing papers in PubMed, 13 syntheses or guidelines pooled it, 373 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. TERT rs10069690 polymorphism and cancers risk: A meta-analysis.Molecular genetics & genomic medicine · 2019
    Pooled it
  13. Pooled it
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

172 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

64 authors at 20 institutions in 11 countries.

Beatrice S MelinDepartment of Radiation Sciences, Umeå University, Umeå, Sweden.
Jill S Barnholtz-SloanCase Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Margaret R WrenschDepartment of Neurological Surgery, School of Medicine, University of California, San Francisco, San Francisco, California, USA.
Christoffer JohansenInstitute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark and Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Dora Il'yasovaDepartment of Epidemiology and Biostatistics, School of Public Health, Georgia State University, Atlanta, Georgia, USA.
Ben KinnersleyDivision of Genetics and Epidemiology, Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0003-1783-6296
Quinn T OstromCase Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Karim LabrecheDivision of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
Yanwen ChenCase Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Georgina ArmstrongDepartment of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
Yanhong LiuDepartment of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
Jeanette E Eckel-PassowDivision of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Paul A DeckerDivision of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Marianne LabussièreSorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, Paris, France.
Ahmed IdbaihSorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, Paris, France.
Khe Hoang-XuanSorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, Paris, France.
Anna-Luisa Di StefanoSorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, Paris, France.ORCID http://orcid.org/0000-0003-1746-0647
Karima MokhtariSorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, Paris, France.
Jean-Yves DelattreSorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, Paris, France.
Peter BroderickDivision of Genetics and Epidemiology, Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-8348-5829
Pilar GalanUniversité Paris 13 Sorbonne Paris Cité, INSERM U557, INRA U1125, CNAM, Paris, France.
Konstantinos GousiasDepartment of Neurosurgery, University of Bonn Medical Center, Bonn, Germany.
Johannes SchrammDepartment of Neurosurgery, University of Bonn Medical Center, Bonn, Germany.
Minouk J SchoemakerDivision of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
Sarah J FlemingCentre for Epidemiology and Biostatistics, Faculty of Medicine and Health, University of Leeds, Leeds, UK.
Stefan HermsCentre for Epidemiology and Biostatistics, Faculty of Medicine and Health, University of Leeds, Leeds, UK.
Stefanie HeilmannInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Heinz-Erich WichmannHelmholtz Center Munich, Institute of Epidemiology I, Munich, Germany.
Stefan Schreiber1st Medical Department, University Clinic Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Anthony SwerdlowDivision of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
Mark LathropGénome Québec, Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
Matthias SimonDepartment of Neurosurgery, University of Bonn Medical Center, Bonn, Germany.
Marc SansonSorbonne Universités UPMC Univ Paris 06, INSERM CNRS, U1127, UMR 7225, ICM, Paris, France.
Ulrika AnderssonDepartment of Radiation Sciences, Umeå University, Umeå, Sweden.
Preetha RajaramanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.ORCID http://orcid.org/0000-0001-6649-999X
Stephen ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Martha LinetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Zhaoming WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Meredith YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
GliomaScan Consortium
John K WienckeDepartment of Neurological Surgery, School of Medicine, University of California, San Francisco, San Francisco, California, USA.
Helen HansenDepartment of Neurological Surgery, School of Medicine, University of California, San Francisco, San Francisco, California, USA.
Lucie McCoyDepartment of Neurological Surgery, School of Medicine, University of California, San Francisco, San Francisco, California, USA.
Terri RiceDepartment of Neurological Surgery, School of Medicine, University of California, San Francisco, San Francisco, California, USA.
Matthew L KoselDivision of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Hugues SicotteDivision of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Christopher I AmosDepartment of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Jonine L BernsteinDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Faith DavisSchool of Public Health, University of Alberta, Edmonton, Alberta, Canada.
Dan LachanceDepartment of Neurology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, Minnesota, USA.
Ching LauDepartment of Pediatrics, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
Ryan T MerrellDepartment of Neurology, NorthShore University HealthSystem, Evanston, Illinois, USA.
Joellen ShildkrautDuke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA.
Francis Ali-OsmanDuke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA.
Siegal SadetzkiCancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Michael ScheurerDepartment of Pediatrics, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
Sanjay SheteDepartment of Biostatistics, University of Texas Maryland Anderson Cancer Center, Houston, Texas, USA.
Rose K LaiDepartments of Neurology and Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Elizabeth B ClausSchool of Public Health, Yale University, New Haven, Connecticut, USA.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Robert B JenkinsDepartment of Laboratory Medicine and Pathology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, Minnesota, USA.
Richard S HoulstonDivision of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
Melissa L BondyDepartment of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
Centre National de la Recherche Scientifique · FRMayo Clinic · USBaylor College of Medicine · USInstitute of Cancer Research · GBNational Cancer Institute · USUniversity of Bonn · DEUniversity of California, San Francisco · USCase Comprehensive Cancer CenterShahrekord University · IRUmeå University · SEUniversity of Leeds · GBBoston University · USConservatoire National des Arts et Métiers · FRDartmouth College · USDuke Institute for Health Innovation · USDurham Technical Community College · USGenome Canada · CAGeorgia State University · USHelmholtz Zentrum München · DENorthShore University HealthSystem · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang · 2002 to 2026
$57.4M
CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
Targeted MV-CEA as a Potent Antitumor Agent against GBMP50CA108961 · NCI · MAYO CLINIC ROCHESTER · PI O'NEILL, BRIAN PATRICK · 2004 to 2015
$22.5M
GENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5M
International Case Control Study of Malignant GliomaR01CA139020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2010 to 2015
$16.0M
Laboratory of Genetic SusceptibilityZIACP010227 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI CHANOCK, STEPHEN J. · 2015 to 2025
$8.6M
Biomarkers of survival in glioma epidemiologyR01CA126831 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 2008 to 2013
$2.5M
NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS K07 CA181480NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA023108NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA097257NCI NIH HHS P50 CA108961NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA126831NCI NIH HHS R01 CA139020NCRR NIH HHS UL1 RR024131NINDS NIH HHS RC1 NS068222Wellcome Trust
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10

Indexed as

Brain NeoplasmsGenetic Predisposition to DiseaseGenome-Wide Association StudyGlioblastomaGliomaAllelesGene Expression Regulation, NeoplasticGenotypeHumansPolymorphism, Single NucleotideQuantitative Trait Loci

Identifiers

PMID28346443
PMCPMC5558246
OpenAlexW2602986494

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.