Evidence map›Paper›PMID 28346426›Full record

ArticleOncogene2017

MRL proteins cooperate with activated Ras in glia to drive distinct oncogenic outcomes.

E Taylor, N Alqadri, L Dodgson, D Mason, E Lyulcheva, G Messina, D Bennett

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The True Story ofFrontiers in physiology · 2019
    Review
  6. Modelling Cooperative Tumorigenesis inBioMed research international · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

E TaylorDepartment of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
N AlqadriDepartment of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
L DodgsonDepartment of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
D MasonCentre for Cell Imaging, Biosciences Building, University of Liverpool, Liverpool, UK.
E LyulchevaDepartment of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
G MessinaDepartment of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
D BennettDepartment of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
University of Liverpool · GB

Funding

Cancer Research UK A11834Cancer Research UK A6678Medical Research Council MR/K015931/1
6 · The paper itself

Abstract

The Mig10/RIAM/Lpd (MRL) adapter protein Lpd regulates actin dynamics through interactions with Scar/WAVE and Ena/VASP proteins to promote the formation of cellular protrusions and to stimulate invasive migration. However, the ability of MRL proteins to interact with multiple actin regulators and to promote serum response factor (SRF) signalling has raised the question of whether MRL proteins employ alternative downstream mechanisms to drive oncogenic processes in a context-dependent manner. Here, using a Drosophila model, we show that overexpression of either human Lpd or its Drosophila orthologue Pico can promote growth and invasion of Ras

Indexed as

AnimalsBrain NeoplasmsCarrier ProteinsCell Transformation, NeoplasticDisease Models, AnimalDrosophilaDrosophila ProteinsGliomaHumansImage Processing, Computer-AssistedImmunohistochemistryMembrane ProteinsNeurogliaOncogenesras ProteinsSerum Response FactorCarrier ProteinsDrosophila ProteinsMembrane ProteinsPico protein, DrosophilaRAPH1 protein, humanras ProteinsSerum Response Factor

Identifiers

PMID28346426
PMCPMC5537612
OpenAlexW2597788922

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.