Evidence map›Paper›PMID 28346375›Full record

ReviewPharmaceutics2017

Liposomal Formulations in Clinical Use: An Updated Review.

Upendra Bulbake, Sindhu Doppalapudi, Nagavendra Kommineni, Wahid Khan

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Pharmaceutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 788 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
788citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03420638 phase4recruitingnot on this mapstarted 2018, after this paper: background citation

Randomized Clinical Trial Examining Use of Adjunct EXPAREL for Post-tonsillectomy Pain Management in Adults

TypeinterventionalSponsorPaul HoffRan2018 to 2021Enrolled38ConditionsTonsillectomyArmsAdjunct Exparel (bupivacaine liposome suspension 1.3%), Standard Care
NCT07254650 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Phase IIb, Randomized, Double-Blinded, Three-Arm Clinical Trial: The Study of Liposomal Bupivacaine Via Intercostal Nerve Block, Serratus Anterior Plane Block, or Combination Block for Pain Control After Robotic Thoracic Surgery

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2026 to 2028Enrolled300ConditionsLung Cancer (Diagnosis)ArmsArm 1 "LipoB-I": Liposomal Bupivacaine via Multi-Level Intercostal Nerve Block, Arm 2 "LipoB-S": Liposomal Bupivacaine via Serratus Anterior Plane Block, Arm 3 "LipoB-C": Liposomal Bupivacaine Administered via Combination Block
3 · Its place in the literature

Who cites it

788 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Liposomes from red betel (Open veterinary journal · 2025
    Pooled it
  2. Trial
  3. Fabrication of vitamin BInternational journal of pharmaceutics: X · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Doubly protected ester prodrug of 5-aminolevulinic acid for enhanced cell uptake and photoinactivation.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  11. Article
  12. Article
  13. A real-world analysis of FDA Adverse Event Reporting System (FAERS) events for liposomal nanoparticle-formulated and conventional anticancer irinotecan.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review

728 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Upendra BulbakeDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, India. upendra.bulbake@gmail.com.
Sindhu DoppalapudiDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, India. dsdoppalapudisindhu@gmail.com.
Nagavendra KommineniDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, India. nagavendra.kommineni@gmail.com.
Wahid KhanDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, India. wahid@niperhyd.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liposomes are the first nano drug delivery systems that have been successfully translated into real-time clinical applications. These closed bilayer phospholipid vesicles have witnessed many technical advances in recent years since their first development in 1965. Delivery of therapeutics by liposomes alters their biodistribution profile, which further enhances the therapeutic index of various drugs. Extensive research is being carried out using these nano drug delivery systems in diverse areas including the delivery of anti-cancer, anti-fungal, anti-inflammatory drugs and therapeutic genes. The significant contribution of liposomes as drug delivery systems in the healthcare sector is known by many clinical products, e.g., Doxil

Indexed as

clinical trialsdrug deliveryliposomesliposome technologymarketed productsnanotechnologytherapeutics

Identifiers

PMID28346375
PMCPMC5489929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.