Evidence map›Paper›PMID 28346137›Full record

ArticleeLife2017

Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity.

Michael P Meers, Telmo Henriques, Christopher A Lavender, Daniel J McKay, Brian D Strahl, Robert J Duronio, Karen Adelman, A Gregory Matera

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Set2 and H3K36 regulate thebioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Article
  12. Lysine-36 ofbioRxiv : the preprint server for biology · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Michael P MeersCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0003-3438-3938
Telmo HenriquesEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Science, Durham, United States.
Christopher A LavenderIntegrative Bioinformatics Support Group, National Institute of Environmental Health Science, Durham, United States.
Daniel J McKayCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.
Brian D StrahlDepartment of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, United States.
Robert J DuronioCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.
Karen AdelmanEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Science, Durham, United States.ORCID 0000-0001-5364-334X
A Gregory MateraCurriculum in Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, United States.ORCID 0000-0002-6406-0630
University of North Carolina at Chapel Hill · USNational Institute of Environmental Health Sciences · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Drosophila Transgenic RNAi Resource ProjectR01GM084947 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2008 to 2019
$9.8M
NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
Investigating Transcriptional Responses to the EnvironmentZ01ES101987 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ADELMAN, KAREN L · 2006 to 2008
$2.8M
Engineering histone genes to interrogate the epigenetic code in space and timeR01DA036897 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DURONIO, ROBERT J, MATERA, A. GREGORY · 2013 to 2017
$2.2M
Studying the role of H3K36 methylation in development and gene expressionF31CA177088 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEERS, MICHAEL P · 2014 to 2016
$91k
Intramural NIH HHS Z01 ES101987NCI NIH HHS F31 CA177088NCI NIH HHS P30 CA016086NIDA NIH HHS R01 DA036897NIGMS NIH HHS R01 GM084947NIGMS NIH HHS T32 GM007092
6 · The paper itself

Abstract

Histone H3 lysine 36 methylation (H3K36me) is thought to participate in a host of co-transcriptional regulatory events. To study the function of this residue independent from the enzymes that modify it, we used a 'histone replacement' system in

Indexed as

Gene Expression RegulationProtein Processing, Post-TranslationalTranscription, GeneticAmino Acid SubstitutionAnimalsDrosophilaGene Expression ProfilingHistonesMethylationMutation, MissenseHistoneschromosomesD. melanogasterepigeneticsevolutionary biologygenesgenomicsRNAsplicing

Identifiers

PMID28346137
PMCPMC5404926
OpenAlexW2598325818

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.