Evidence map›Paper›PMID 28346136›Full record

ArticleeLife2017

Environment determines evolutionary trajectory in a constrained phenotypic space.

David T Fraebel, Harry Mickalide, Diane Schnitkey, Jason Merritt, Thomas E Kuhlman, Seppe Kuehn

Abstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Inheritance of extraordinary metabolic activity from parental bacteria individuals.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Role of a single MCP in evolutionary adaptation ofApplied and environmental microbiology · 2025
    Article
  9. Article
  10. Nongenetic adaptation by collective migration.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Direct measurement of dynamic attractant gradients reveals breakdown of the Patlak-Keller-Segel chemotaxis model.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Convergent genetic adaptation ofFrontiers in molecular biosciences · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David T FraebelCenter for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, United States.ORCID 0000-0002-8668-3476
Harry MickalideCenter for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, United States.
Diane SchnitkeyCenter for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, United States.
Jason MerrittCenter for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, United States.
Thomas E KuhlmanCenter for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, United States.
Seppe KuehnCenter for the Physics of Living Cells, University of Illinois at Urbana-Champaign, Urbana, United States.ORCID 0000-0002-4130-6845

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Constraints on phenotypic variation limit the capacity of organisms to adapt to the multiple selection pressures encountered in natural environments. To better understand evolutionary dynamics in this context, we select

Indexed as

Adaptation, BiologicalBiological Variation, PopulationEnvironmentCulture MediaEscherichia coliLocomotionSelection, GeneticCulture Mediachemotaxiscomputational biologyE. colievolutionary biologyexperimental evolutiongenomicsphenotypic constraintsphenotypic spacesystems biologytrade-off

Identifiers

PMID28346136
PMCPMC5441876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.