ArticleOrganic letters2017
Macrophilone A: Structure Elucidation, Total Synthesis, and Functional Evaluation of a Biologically Active Iminoquinone from the Marine Hydroid Macrorhynchia philippina.
Article in Organic letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Thiazination ofOrganic chemistry frontiers : an international journal of organic chemistry · 2026Article
- Marine Natural Products from Flora and Fauna of the Western Australian Coast: Taxonomy, Isolation and Biological Activity.Molecules (Basel, Switzerland) · 2023Review
- Current Perspectives on Pyrroloiminoquinones: Distribution, Biosynthesis and Drug Discovery Potential.Molecules (Basel, Switzerland) · 2022Review
- Biochemical and Toxinological Characterization of Venom fromBioMed research international · 2022Article
- Marine Pyrrole Alkaloids.Marine drugs · 2021Review
- Current Status of SUMOylation Inhibitors.Current medicinal chemistry · 2021Review
- Discovery of Mitochondrial Transcription Inhibitors Active in Pancreatic Cancer Cells.ChemMedChem · 2020Article
- Creating and screening natural product libraries.Natural product reports · 2020Review
- Macrophilones from the Marine Hydroid Macrorhynchia philippina Can Inhibit ERK Cascade Signaling.Journal of natural products · 2018Article
- Crystal structure of (Acta crystallographica. Section E, Crystallographic communications · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
A previously uncharacterized pyrroloiminoquinone natural product, macrophilone A, was isolated from the stinging hydroid Macrorhynchia philippina. The structure was assigned utilizing long-range NMR couplings and DFT calculations and proved by a concise, five-step total synthesis. Macrophilone A and a synthetic analogue displayed potent biological activity, including increased intracellular reactive oxygen species levels and submicromolar cytotoxicity toward lung adenocarcinoma cells.
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Registered trials
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