Evidence map›Paper›PMID 28345871›Full record

ArticleACS nano2017

In Vivo Targeting and Positron Emission Tomography Imaging of Tumor with Intrinsically Radioactive Metal-Organic Frameworks Nanomaterials.

Daiqin Chen, Dongzhi Yang, Casey A Dougherty, Weifei Lu, Hongwei Wu, Xianran He, Ting Cai, Marcian E Van Dort, Brian D Ross, Hao Hong

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 299 citations in OpenAlex.

  1. Pooled it
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  3. Contrast Agents for Enhanced Bioimaging: A Comprehensive Review.Chembiochem : a European journal of chemical biology · 2026
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Daiqin ChenDepartment of Radiology, Center for Molecular Imaging, University of Michigan , Ann Arbor, Michigan 48109-2200, United States.
Dongzhi YangDepartment of Radiology, Center for Molecular Imaging, University of Michigan , Ann Arbor, Michigan 48109-2200, United States.
Casey A DoughertyDepartment of Radiology, Center for Molecular Imaging, University of Michigan , Ann Arbor, Michigan 48109-2200, United States.
Weifei LuDepartment of Radiology, Center for Molecular Imaging, University of Michigan , Ann Arbor, Michigan 48109-2200, United States.
Hongwei WuDepartment of Radiology, Center for Molecular Imaging, University of Michigan , Ann Arbor, Michigan 48109-2200, United States.
Xianran HeKey Laboratory of Optoelectronic Chemical Materials and Devices, Jianghan University , Wuhan, Hubei 430056, China.
Ting CaiSchool of Pharmacy, China Pharmaceutical University , Nanjing 210009, China.ORCID 0000-0001-7510-9295
Marcian E Van DortDepartment of Radiology, Center for Molecular Imaging, University of Michigan , Ann Arbor, Michigan 48109-2200, United States.ORCID 0000-0002-6538-4661
Brian D RossDepartment of Radiology, Center for Molecular Imaging, University of Michigan , Ann Arbor, Michigan 48109-2200, United States.
Hao HongDepartment of Radiology, Center for Molecular Imaging, University of Michigan , Ann Arbor, Michigan 48109-2200, United States.ORCID 0000-0002-9730-9367
University of Michigan · USChina Pharmaceutical University · CNJianghan University · CNXuzhou Medical College · CN

Funding

QUANTITATION OF HUMAN BRAIN TUMOR THERAPY RESPONSE BY MRP01CA085878 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHENEVERT, THOMAS L · 2001 to 2017
$31.9M
NCI NIH HHS P01 CA085878
6 · The paper itself

Abstract

Nanoscale metal-organic frameworks (nMOF) materials represent an attractive tool for various biomedical applications. Due to the chemical versatility, enormous porosity, and tunable degradability of nMOFs, they have been adopted as carriers for delivery of imaging and/or therapeutic cargos. However, the relatively low stability of most nMOFs has limited practical in vivo applications. Here we report the production and characterization of an intrinsically radioactive UiO-66 nMOF (

Indexed as

AnimalsAntineoplastic AgentsCell LineCell Line, TumorContrast MediaDoxorubicinDrug CarriersDrug LiberationFemaleHumansMetal-Organic FrameworksMice, Inbred BALB CMolecular Targeted TherapyNanoparticlesNeoplasmsPeptidesAntineoplastic AgentsContrast MediaDoxorubicinDrug CarriersMetal-Organic FrameworksPeptidesPolyethylene GlycolsRadioisotopesRadiopharmaceuticalsZirconiumZirconium-89cancer targetingimage-guided drug deliveryintrinsic radiolabelmetal−organic frameworks (MOF)nucleolinpositron emission tomography

Identifiers

PMID28345871
PMCPMC5477053
OpenAlexW2603383977

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.