Evidence map›Paper›PMID 28345808›Full record

ArticleMolecular carcinogenesis2017

Molecular genetic analysis of the melanoma regulatory locus in Xiphophorus interspecies hybrids.

Yuan Lu, Mikki Boswell, William Boswell, Susanne Kneitz, Michael Hausmann, Barbara Klotz, Janine Regneri, Markita Savage, Angel Amores, John Postlethwait and 3 more

Abstract read
In one paragraph

Article in Molecular carcinogenesis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Non-Additive and Asymmetric Allelic Expression ofAnimals : an open access journal from MDPI · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Oncogenic allelic interaction inProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Yuan LuThe Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, Texas.ORCID 0000-0002-2420-4804
Mikki BoswellThe Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, Texas.
William BoswellThe Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, Texas.
Susanne KneitzPhysiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.
Michael HausmannPhysiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.
Barbara KlotzPhysiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.
Janine RegneriPhysiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.
Markita SavageThe Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, Texas.
Angel AmoresInstitute of Neuroscience, University of Oregon, Eugene, Oregon.
John PostlethwaitInstitute of Neuroscience, University of Oregon, Eugene, Oregon.
Wesley WarrenThe Genome Institute, Washington University School of Medicine, St. Louis, Missouri.
Manfred SchartlPhysiological Chemistry, Biozentrum, University of Würzburg, Würzburg, Germany.
Ronald WalterThe Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry, Texas State University, San Marcos, Texas.
Texas State University · USUniversity of Würzburg · DEUniversity of Oregon · USWashington University in St. Louis · US

Funding

Enhanced Development of the Xiphophorus Model System R24-OD-011120R24OD011120 · OD · TEXAS STATE UNIVERSITY · PI GABOR, CAITLIN, LU, YUAN · 2012 to 2019
$5.3M
Development of Aquatic Model Resources for Therapeutic ScreensR24OD018555 · OD · UNIVERSITY OF OREGON · PI POSTLETHWAIT, JOHN H. · 2014 to 2017
$2.6M
Advancing the Scientific Potential of Transcriptomics in Aquatic ModelsR24OD011199 · OD · UNIVERSITY OF OREGON · PI CRESKO, WILLIAM A, POSTLETHWAIT, JOHN H. · 2012 to 2014
$1.8M
Whole genome assembly resources for aquatic models of human diseaseR24OD011198 · OD · WASHINGTON UNIVERSITY · PI WARREN, WESLEY CHARLES · 2012 to 2019
$1.4M
NIH HHS R24 OD011120NIH HHS R24 OD011198NIH HHS R24 OD011199NIH HHS R24 OD018555
6 · The paper itself

Abstract

Development of spontaneous melanoma in Xiphophorus interspecies backcross hybrid progeny, (X. hellerii × [X. maculatus Jp 163 A × X. hellerii]) is due to Mendelian segregation of a oncogene (xmrk) and a molecularly uncharacterized locus, called R(Diff), on LG5. R(Diff) is thought to suppresses the activity of xmrk in healthy X. maculatus Jp 163 A parental species that rarely develop melanoma. To better understand the molecular genetics of R(Diff), we utilized RNA-Seq to study allele-specific gene expression of spontaneous melanoma tumors and corresponding normal skin samples derived from 15 first generation backcross (BC

Indexed as

Gene Expression Regulation, NeoplasticAllelesAnimalsCrosses, GeneticCyprinodontiformesFemaleFish ProteinsGenetic LociHybridization, GeneticMaleMelanoma, ExperimentalReceptor Protein-Tyrosine KinasesSkinSkin NeoplasmsFish ProteinsReceptor Protein-Tyrosine KinasesXmrk protein, Xiphophorusallele specific gene expressionbioinformaticsgenetic interactionGordon-Kosswig modelinterspecies hybrids

Identifiers

PMID28345808
PMCPMC5767473
OpenAlexW2601419626

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.