ArticleScientific reports2017
Brain arousal regulation as response predictor for antidepressant therapy in major depression.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Resting and TMS-EEG markers of treatment response in major depressive disorder: A systematic review.Frontiers in human neuroscience · 2022Pooled it
- Electroencephalographic Biomarkers for Treatment Response Prediction in Major Depressive Illness: A Meta-Analysis.The American journal of psychiatry · 2019Pooled it
- Evaluation of emotional arousal level and depression severity using voice-derived sound pressure change acceleration.Scientific reports · 2021Trial
- Changes in brain arousal (EEG-vigilance) after therapeutic sleep deprivation in depressive patients and healthy controls.Scientific reports · 2018Trial
- Functional and structural connectivity of thalamic subnuclei in major depressive disorder at 7 Tesla.Psychiatry and clinical neurosciences · 2026Article
- Hormonal contraceptives and EEG biomarkers for antidepressant treatment response in women.Communications medicine · 2026Article
- Arousal effects on oscillatory dynamics in the non-human primate brain.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- EEG-vigilance regulation is associated with and predicts ketamine response in major depressive disorder.Translational psychiatry · 2024Article
- Neurobiological Underpinnings of Hyperarousal in Depression: A Comprehensive Review.Brain sciences · 2024Review
- Cognitive-Affective Functions of the Cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Regulation of brain cognitive states through auditory, gustatory, and olfactory stimulation with wearable monitoring.Scientific reports · 2023Article
- The impact of emotional dysregulation and comorbid depressive symptoms on clinical features, brain arousal, and treatment response in adults with ADHD.Frontiers in psychiatry · 2023Article
- EEG Neurofeedback for Anxiety Disorders and Post-Traumatic Stress Disorders: A Blueprint for a Promising Brain-Based Therapy.Current psychiatry reports · 2021Review
- The Big Five Personality Traits and Brain Arousal in the Resting State.Brain sciences · 2021Article
- Increased occurrence of PTSD symptoms in adolescents with major depressive disorder soon after the start of the COVID-19 outbreak in China: a cross-sectional survey.BMC psychiatry · 2021Article
- Fatigue and brain arousal in patients with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2021Article
- Special Report on the Impact of the COVID-19 Pandemic on Clinical EEG and Research and Consensus Recommendations for the Safe Use of EEG.Clinical EEG and neuroscience · 2021Article
- Brain Arousal as Measured by EEG-Assessment Differs Between Children and Adolescents With Attention-Deficit/Hyperactivity Disorder (ADHD) and Depression.Frontiers in psychiatry · 2021Article
- Prepronociceptin-Expressing Neurons in the Extended Amygdala Encode and Promote Rapid Arousal Responses to Motivationally Salient Stimuli.Cell reports · 2020Article
- Evaluation of the Severity of Major Depression Using a Voice Index for Emotional Arousal.Sensors (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A tonically high level of brain arousal and its hyperstable regulation is supposed to be a pathogenic factor in major depression. Preclinical studies indicate that most antidepressants may counteract this dysregulation. Therefore, it was hypothesized that responders to antidepressants show a) a high level of EEG-vigilance (an indicator of brain arousal) and b) a more stable EEG-vigilance regulation than non-responders. In 65 unmedicated depressed patients 15-min resting-state EEGs were recorded off medication (baseline). In 57 patients an additional EEG was recorded 14 ± 1 days following onset of antidepressant treatment (T1). Response was defined as a ≥50% HAMD-17-improvement after 28 ± 1 days of treatment (T2), resulting in 29 responders and 36 non-responders. Brain arousal was assessed using the Vigilance Algorithm Leipzig (VIGALL 2.1). At baseline responders and non-responders differed in distribution of overall EEG-vigilance stages (F
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.