ArticleScientific reports2017
Sexual epigenetics: gender-specific methylation of a gene in the sex determining region of Populus balsamifera.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 76 citations in OpenAlex.
- Article
- Integrated methylome and transcriptome analysis provides insight into DNA methylation-mediated networks in sexual dimorphism of Vernicia montana.BMC plant biology · 2026Article
- Sexy ways: approaches to studying plant sex chromosomes.Journal of experimental botany · 2024Review
- Reciprocal expression of MADS-box genes and DNA methylation reconfiguration initiate bisexual cones in spruce.Communications biology · 2024Article
- Gender specific SNP markers in Coscinium fenestratum (Gaertn.) Colebr. for resource augmentation.Molecular biology reports · 2024Article
- Genomic and transcriptomic analyses reveal polygenic architecture for ecologically important traits in aspen (Ecology and evolution · 2023Article
- Comparative transcriptomic analysis of male and females in the dioecious weeds Amaranthus palmeri and Amaranthus tuberculatus.BMC plant biology · 2023Article
- Evolution of plant sex and molecular mechanisms underlying plants sex separation.Forestry research · 2023Review
- Beyond the Primary Structure of Nucleic Acids: Potential Roles of Epigenetics and Noncanonical Structures in the Regulations of Plant Growth and Stress Responses.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Chromosome-scale assemblies of the male and female Populus euphratica genomes reveal the molecular basis of sex determination and sexual dimorphism.Communications biology · 2022Article
- Sex-specific DNA methylation: impact on human health and development.Molecular genetics and genomics : MGG · 2022Review
- Article
- Identification of an Epigenetically Marked Locus within the Sex Determination Region of Channel Catfish.International journal of molecular sciences · 2022Article
- A convergent mechanism of sex determination in dioecious plants: Distinct sex-determining genes display converged regulation on floral B-class genes.Frontiers in plant science · 2022Review
- Genome-wide association mapping uncovers sex-associated copy number variation markers and female hemizygous regions on the W chromosome in Salix viminalis.BMC genomics · 2021Article
- DNA methylation is involved in sexual differentiation and sex chromosome evolution in the dioecious plant garden asparagus.Horticulture research · 2021Article
- Inferring the Genetic Basis of Sex Determination from the Genome of a Dioecious Nightshade.Molecular biology and evolution · 2021Article
- Differential DNA methylation and gene expression during development of reproductive and vegetative organs in Ilex species.Journal of plant research · 2021Article
- A General Model to Explain Repeated Turnovers of Sex Determination in the Salicaceae.Molecular biology and evolution · 2021Article
- Updated Genome Assembly of Bighead Carp (Frontiers in genetics · 2021Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methylation has frequently been implicated in gender determination in plants. The recent discovery of the sex determining region (SDR) of balsam poplar, Populus balsamifera, pinpointed 13 genes with differentiated X and Y copies. We tested these genes for differential methylation using whole methylome sequencing of xylem tissue of multiple individuals grown under field conditions in two common gardens. The only SDR gene to show a marked pattern of gender-specific methylation is PbRR9, a member of the two component response regulator (type-A) gene family, involved in cytokinin signalling. It is an ortholog of Arabidopsis genes ARR16 and ARR17. The strongest patterns of differential methylation (mostly male-biased) are found in the putative promoter and the first intron. The 4th intron is strongly methylated in both sexes and the 5th intron is unmethylated in both sexes. Using a statistical learning algorithm we find that it is possible accurately to assign trees to gender using genome-wide methylation patterns alone. The strongest predictor is the region coincident with PbRR9, showing that this gene stands out against all genes in the genome in having the strongest sex-specific methylation pattern. We propose the hypothesis that PbRR9 has a direct, epigenetically mediated, role in poplar sex determination.
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