ArticleScientific reports2017
Identification and comparative analysis of the epidermal differentiation complex in snakes.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair and Other Cornified Epithelial Structures.Animals : an open access journal from MDPI · 2025Review
- Convergent Evolution Has Led to the Loss of Claw Proteins in Snakes and Worm Lizards.Genome biology and evolution · 2025Article
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- Comparative genomics of sirenians reveals evolution of filaggrin and caspase-14 upon adaptation of the epidermis to aquatic life.Scientific reports · 2024Article
- Insights into the adaptive evolution of chromosome and essential traits through chromosome-level genome assembly ofiScience · 2024Article
- Comparative genomics of monotremes provides insights into the early evolution of mammalian epidermal differentiation genes.Scientific reports · 2024Article
- Development-Associated Genes of the Epidermal Differentiation Complex (EDC).Journal of developmental biology · 2024Review
- The Story of the Finest Armor: Developmental Aspects of Reptile Skin.Journal of developmental biology · 2023Review
- Evolutionary diversification of epidermal barrier genes in amphibians.Scientific reports · 2022Article
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- Review
- Article
- Identification of epidermal differentiation genes of the tuatara provides insights into the early evolution of lepidosaurian skin.Scientific reports · 2020Article
- Complex Gene Loss and Duplication Events Have Facilitated the Evolution of Multiple Loricrin Genes in Diverse Bird Species.Genome biology and evolution · 2019Article
- Review: mapping proteins localized in adhesive setae of the tokay gecko and their possible influence on the mechanism of adhesion.Protoplasma · 2018Review
- Recent evolution of the human skin barrier.Experimental dermatology · 2018Review
- Comparative Analysis of Epidermal Differentiation Genes of Crocodilians Suggests New Models for the Evolutionary Origin of Avian Feather Proteins.Genome biology and evolution · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The epidermis of snakes efficiently protects against dehydration and mechanical stress. However, only few proteins of the epidermal barrier to the environment have so far been identified in snakes. Here, we determined the organization of the Epidermal Differentiation Complex (EDC), a cluster of genes encoding protein constituents of cornified epidermal structures, in snakes and compared it to the EDCs of other squamates and non-squamate reptiles. The EDC of snakes displays shared synteny with that of the green anole lizard, including the presence of a cluster of corneous beta-protein (CBP)/beta-keratin genes. We found that a unique CBP comprising 4 putative beta-sheets and multiple cysteine-rich EDC proteins are conserved in all snakes and other squamates investigated. Comparative genomics of squamates suggests that the evolution of snakes was associated with a gene duplication generating two isoforms of the S100 fused-type protein, scaffoldin, the origin of distinct snake-specific EDC genes, and the loss of other genes that were present in the EDC of the last common ancestor of snakes and lizards. Taken together, our results provide new insights into the evolution of the skin in squamates and a basis for the characterization of the molecular composition of the epidermis in snakes.
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