ArticleScientific reports2017
Comprehensive track-structure based evaluation of DNA damage by light ions from radiotherapy-relevant energies down to stopping.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03561220 (A Prospective Comparative Study of Outcomes With Proton and Photon Radiation in Prostate Cancer), which is not on this map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Comparative Study of Outcomes With Proton and Photon Radiation in Prostate Cancer
Who cites it
75 citing papers in PubMed.
- Comprehensive database of track-structure simulations on DNA damage by H-Fe ions up to 1 GeV/u for space radiation biology.Scientific reports · 2026Article
- A polymer physics model of the interphase cell nucleus for radiobiological simulations.Scientific reports · 2026Article
- Base-excision repair increases DNA double-strand break clustering within heavy-ion tracks and modulates repair at δ-electron-induced breaks.Scientific reports · 2026Article
- Article
- Unravelling the impact of linear energy transfer on micronuclei induction from proton and photon irradiation.Scientific reports · 2025Article
- TOPAS-nBio-Reg: a regression testing system for track structure simulations in TOPAS-nBio.Physics in medicine and biology · 2025Article
- Mapping neutron biological effectiveness for DNA damage induction as a function of incident energy and depth in a human sized phantom.Scientific reports · 2025Article
- Significance of the proton energy loss mechanism to gold nanoparticles in proton therapy: a Geant4 simulation.Scientific reports · 2024Article
- Quantitative analysis of dose dependent DNA fragmentation in dry pBR322 plasmid using long read sequencing and Monte Carlo simulations.Scientific reports · 2024Article
- Lithium inelastic cross-sections and their impact on micro and nano dosimetry of boron neutron capture.Physics in medicine and biology · 2024Article
- DNA-damage RBE assessment for combined boron and gadolinium neutron capture therapy.Journal of applied clinical medical physics · 2024Article
- Simulation of Radiation-Induced DNA Damage and Protection by Histones Using the Code RITRACKS.Biotech (Basel (Switzerland)) · 2024Article
- Radiation-induced DNA double-strand breaks in cortisol exposed fibroblasts as quantified with the novel foci-integrated damage complexity score (FIDCS).Scientific reports · 2024Article
- RadPhysBio: A Radiobiological Database for the Prediction of Cell Survival upon Exposure to Ionizing Radiation.International journal of molecular sciences · 2024Article
- Radium deposition in human brain tissue: A Geant4-DNA Monte Carlo toolkit study.Zeitschrift fur medizinische Physik · 2024Article
- Effects of Differing Underlying Assumptions in In Silico Models on Predictions of DNA Damage and Repair.Radiation research · 2023Article
- High-LET radiation induces large amounts of rapidly-repaired sublethal damage.Scientific reports · 2023Article
- Prediction of DNA rejoining kinetics and cell survival after proton irradiation for V79 cells using Geant4-DNA.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2023Article
- Track Structure-Based Simulations on DNA Damage Induced by Diverse Isotopes.International journal of molecular sciences · 2022Article
- Assessing the DNA Damaging Effectiveness of Ionizing Radiation Using Plasmid DNA.International journal of molecular sciences · 2022Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Track structures and resulting DNA damage in human cells have been simulated for hydrogen, helium, carbon, nitrogen, oxygen and neon ions with 0.25-256 MeV/u energy. The needed ion interaction cross sections have been scaled from those of hydrogen; Barkas scaling formula has been refined, extending its applicability down to about 10 keV/u, and validated against established stopping power data. Linear energy transfer (LET) has been scored from energy deposits in a cell nucleus; for very low-energy ions, it has been defined locally within thin slabs. The simulations show that protons and helium ions induce more DNA damage than heavier ions do at the same LET. With increasing LET, less DNA strand breaks are formed per unit dose, but due to their clustering the yields of double-strand breaks (DSB) increase, up to saturation around 300 keV/μm. Also individual DSB tend to cluster; DSB clusters peak around 500 keV/μm, while DSB multiplicities per cluster steadily increase with LET. Remarkably similar to patterns known from cell survival studies, LET-dependencies with pronounced maxima around 100-200 keV/μm occur on nanometre scale for sites that contain one or more DSB, and on micrometre scale for megabasepair-sized DNA fragments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.