Evidence map›Paper›PMID 28345618›Full record

ArticleScientific reports2017

PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction.

Xue Qiao, Shi Jia, Jingjing Ye, Xuan Fang, Chenglin Zhang, Yangpo Cao, Chunling Xu, Lifang Zhao, Yi Zhu, Lu Wang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Xue QiaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China.
Shi JiaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China.
Jingjing YeDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China.
Xuan FangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China.
Chenglin ZhangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China.
Yangpo CaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China.
Chunling XuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China.
Lifang ZhaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China.
Yi ZhuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China.
Lu WangCenter for Human Disease Genomics, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China.
Ming ZhengDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100191, China.
Peking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein tyrosine phosphatase interacting protein 51 (PTPIP51) participates in multiple cellular processes, and dysfunction of PTPIP51 is implicated in diseases such as cancer and neurodegenerative disorders. However, there is no functional evidence showing the physiological or pathological roles of PTPIP51 in the heart. We have therefore investigated the role and mechanisms of PTPIP51 in regulating cardiac function. We found that PTPIP51 was markedly upregulated in ischemia/reperfusion heart. Upregulation of PTPIP51 by adenovirus-mediated overexpression markedly increased the contact of mitochondria-sarcoplasmic reticulum (SR), elevated mitochondrial Ca

Indexed as

AnimalsCalciumCalcium SignalingCoronary Artery DiseaseMaleMiceMice, Inbred C57BLMitochondria, HeartMitochondrial ProteinsMyocardial InfarctionMyocardial IschemiaMyocardial Reperfusion InjuryMyocardiumMyocytes, CardiacProtein Tyrosine PhosphatasesReperfusionCalciumMitochondrial ProteinsProtein Tyrosine PhosphatasesPTPIP51 protein, mouse

Identifiers

PMID28345618
PMCPMC5366942
OpenAlexW2599124266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.