ArticleScientific reports2017
Prognosis and value of preoperative radiotherapy in locally advanced rectal signet-ring cell carcinoma.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- A distinct form of colorectal cancer: signet ring cell carcinoma.Translational cancer research · 2026Article
- Analysis of clinicopathological features, treatment modalities, and survival outcomes in advanced gastric and colorectal signet ring cell carcinoma.Discover oncology · 2025Article
- Individualized prediction tool for patients with metastatic gastric signet cell carcinoma.Scientific reports · 2025Article
- A dynamic nomogram for predicting pathologic complete response to neoadjuvant chemotherapy in locally advanced rectal cancer.Cancer medicine · 2024Article
- Systematic review of risk factors, prognosis, and management of colorectal signet-ring cell carcinoma.World journal of gastrointestinal oncology · 2024Article
- The prognostic ability of radiotherapy of different colorectal cancer histological subtypes and tumor sites.Scientific reports · 2023Article
- Rectal Signet Ring Cell Carcinoma: Post-Chemoradiotherapy Evaluation by MRI and Corresponding to Pathology.Frontiers in surgery · 2022Article
- Predictors of Long-Time Survivors in Nonmetastatic Colorectal Signet Ring Cell Carcinoma: A Large Population-Based Study.Gastroenterology research and practice · 2022Article
- Prognostic value of log odds of positive lymph nodes, lymph node ratio, andFrontiers in surgery · 2022Article
- Clinicopathological characteristics and prognosis of signet ring cell carcinoma of the gallbladder.BMC gastroenterology · 2021Article
- Construction and validation a nomogram to predict overall survival for colorectal signet ring cell carcinoma.Scientific reports · 2021Article
- Clinicopathological Features and Survival of Signet-Ring Cell Carcinoma and Mucinous Adenocarcinoma of Right Colon, Left Colon, and Rectum.Pathology oncology research : POR · 2021Article
- Prediction of cancer-specific survival and overall survival in middle-aged and older patients with rectal adenocarcinoma using a nomogram model.Translational oncology · 2021Article
- Prognostic Analysis of Primary Breast Signet Ring Cell Carcinoma and Mucinous Breast Adenocarcinoma: A SEER Population-Based Study.Frontiers in oncology · 2021Article
- Signet ring cell component in pretreatment biopsy predicts pathological response to preoperative chemoradiotherapy in rectal cancer.International journal of clinical oncology · 2020Article
- Factors associated with the survival of colorectal cancer in Mexico.Intestinal research · 2020Article
- Postoperative Radiotherapy Improves Survival in Gastric Signet-Ring Cell Carcinoma: a SEER Database Analysis.Journal of gastric cancer · 2019Article
- Chemotherapy is associated with increased survival from colorectal signet ring cell carcinoma with distant metastasis: A Surveillance, Epidemiology, and End Results database analysis.Cancer medicine · 2019Article
- Predictors and Risk Factors of Pathologic Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer: A Population-Based Analysis.Frontiers in oncology · 2019Article
- Prognostic impact of the number of lymph nodes examined in different stages of colorectal mucinous adenocarcinoma.OncoTargets and therapy · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As well known, signet-ring cell carcinoma (SRCC) is a rare histological subtype of colorectal adenocarcinoma, which has been associated with poor prognosis and resistant to non-surgery therapy compared with common adenocarcinoma. In this study, we assessed the effect of preoperative radiotherapy (PRT) for locally advanced rectal SRCC in a large patient group from the Surveillance, Epidemiology, and End Results program (SEER, 1988-2011) database. SRCC was found in 0.9% (n = 622) rectal cancer (RC) patients in our study. In the PRT setting, SRCC had significantly worse cancer-specific survival than mucinous adenocarcinoma and nonmucinous adenocarcinoma patients (log-rank, P < 0.001). In terms of SRCC, stage III RC patients benefited from PRT (log-rank, P < 0.001) while stage II did not (P = 0.095). The multivariate Cox proportional hazard model showed that PRT was an independent benefit factor in stage III rectal SRCC patients (HR, 0.611; 95% CI, 0.407-0.919; P = 0.018). In conclusion, SRCC was an independent predictor of poor prognosis in stage III RC patients, but not in stage II. In the PRT setting of locally advanced RC, SRCC patients had significantly worse prognosis. PRT was an independent prognostic factor associated with improved survival in stage III rectal SRCC.
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