ArticleScientific reports2017
Associations of parental age with health and social factors in adult offspring. Methodological pitfalls and possibilities.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Parental Age and Childhood Lymphoma and Solid Tumor Risk: A Literature Review and Meta-Analysis.JNCI cancer spectrum · 2022Pooled it
- CD38-activated macrophages drive age-related placental senescence by depleting NADNature communications · 2026Article
- School dropout among children aged 5-17 in Türkiye and related factors: a logistic regression analysis.BMC pediatrics · 2025Article
- Age-related changes in lncRNA expression in sperm.Translational andrology and urology · 2025Article
- No evidence of positive causal effects of maternal and paternal age at first birth on children's test scores at age 10 years.Nature human behaviour · 2025Article
- Analyzing the Impact of Family Structure Changes on Children's Stress Levels Using a Stress Biomarker.Journal of health and social behavior · 2024Article
- The Association Between Maternal Age at Childbirth and Child Nutritional Outcomes: A Cross-sectional Study From Serbian Roma Communities.Global pediatric health · 2024Article
- Rethinking advanced motherhood: a new ethical narrative.Medicine, health care, and philosophy · 2023Review
- Maternal age and the risk of low birthweight and pre-term delivery: a pan-Nordic comparison.International journal of epidemiology · 2023Article
- Associations of parental reproductive age and elevated blood pressure in offspring: An observational study.Frontiers in pediatrics · 2023Article
- Building a family at advanced parental age: a systematic review on the risks and opportunities for parents and their offspring.Human reproduction open · 2023Review
- Children having children: early motherhood and offspring human capital in India.Journal of population economics · 2023Article
- Childhood exposure to parental smoking and life-course overweight and central obesity.Annals of medicine · 2021Article
- Exploring Perinatal Indicators of Infant Social-Emotional Development: A Review of the Replicated Evidence.Clinical child and family psychology review · 2021Review
- Advanced paternal age and risk of schizophrenia in offspring - Review of epidemiological findings and potential mechanisms.Schizophrenia research · 2021Review
- Parental Age and Offspring Childhood Mental Health: A Multi-Cohort, Population-Based Investigation.Child development · 2020Article
- Associations of parental age with offspring all-cause and cause-specific adult mortality.Scientific reports · 2019Article
- Article
- Social Skills in Children at Home and in Preschool.Behavioral sciences (Basel, Switzerland) · 2019Article
- Persistent epigenetic changes in adult daughters of older mothers.Epigenetics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Parental age is increasing rapidly in many countries. Analysis of this potentially important influence on offspring well-being is hampered by strong secular trends and socioeconomic patterning and by a shortage of follow-up data for adult offspring. We used Swedish national data on up to 3,653,938 offspring to consider the associations of parental age with a suite of outcomes in adult offspring, comparing the results from an array of statistical methods for optimal causal inference. The offspring of older mothers had higher BMI, blood pressure, height, intelligence, non-cognitive ability and socioeconomic position. They were less likely to smoke or to be left-handed. Associations with paternal age were strongly, but not completely, attenuated by adjustment for maternal age. Estimates from the commonly-used sibling comparison method were driven primarily by a pathway mediated by offspring date of birth when outcomes showed strong secular trends. These results suggest that the intra-uterine and early life environments provided by older mothers may be detrimental to offspring cardiovascular health, but that their greater life experience and social position may bring intellectual and social advantages to their offspring. The analysis of parental age presents particular challenges, and further methodological developments are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.