ArticleNature communications2017
Direct amidation of esters with nitroarenes.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 178 citations in OpenAlex.
- Direct Mechano-Catalytic Synthesis of Amides Using Brass Balls via Cross-Coupling of Isocyanides With Arylboronic Acids or in Situ Generated N-Aryl-Pyridinium Salts.Chemistry, an Asian journal · 2026Article
- Direct Amidation of Alkynes with Nitroarenes via Heterogeneous Semiconductor TiO₂ Nanotubes.Nature communications · 2026Article
- Amidation of Quinolin-2-yl Esters: Base‑, Catalyst‑, Metal‑, and Solvent-Free Conditions.ACS omega · 2026Article
- Multi-Functional Hybrid Terpolymer Thermosets Based on Thiols Bio-Based Epoxy and Benzoxazine Monomers.Polymers · 2025Article
- Scalable and sustainable reductive amidation of nitroarenes, nitroalkenes, and nitroalkyls with acyl saccharins in aqueous media.Communications chemistry · 2025Article
- Harnessing the Reactivity of Nitroarene Radical Anions to Create Quinoline N-Oxides by Electrochemical Reductive Cyclization.Angewandte Chemie (International ed. in English) · 2025Article
- β-Silyl alkynoates: Versatile reagents for biocompatible and selective amide bond formation.Science advances · 2024Article
- Dual role of nitroarenes as electrophiles and arylamine surrogates in Buchwald-Hartwig-type coupling for C-N bond construction.Chemical science · 2024Article
- Enantioselective nickel-catalyzed Mizoroki-Heck cyclizations of amide electrophiles.Chemical science · 2024Article
- The Development and Mechanistic Study of an Iron-Catalyzed Intramolecular Nitroso Ene Reaction of Nitroarenes.ACS catalysis · 2023Article
- Streamlining the synthesis of amides using Nickel-based nanocatalysts.Nature communications · 2023Article
- Reductive Arylation of Nitroarenes with Chloroarenes: Reducing Conditions Enable New Reactivity from Palladium Catalysts.Journal of the American Chemical Society · 2023Article
- Development of fluorous boronic acid catalysts integrated with sulfur for enhanced amidation efficiency.RSC advances · 2023Article
- A novel reaction mechanism for the synthesis of coconut oil-derived biopolyol for rigid poly(urethane-urea) hybrid foam application.RSC advances · 2023Article
- Photomediated reductive coupling of nitroarenes with aldehydes for amide synthesis.Chemical science · 2022Article
- Base-promoted direct amidation of esters: beyond the current scope and practical applications.RSC advances · 2022Article
- Recent Advances to Mediate Reductive Processes of Nitroarenes Using Single-Electron Transfer, Organomagnesium, or Organozinc Reagents.Synthesis · 2022Article
- Decarboxylative tandem C-N coupling with nitroarenes via SNature communications · 2022Article
- Merging enzymes with chemocatalysis for amide bond synthesis.Nature communications · 2022Article
- Cu-Catalyzed Cross-Coupling of Nitroarenes with Aryl Boronic Acids to Construct Diarylamines.ACS catalysis · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Esters are one of the most common functional groups in natural and synthetic products, and the one-step conversion of the ester group into other functional groups is an attractive strategy in organic synthesis. Direct amidation of esters is particularly appealing due to the omnipresence of the amide moiety in biomolecules, fine chemicals, and drug candidates. However, efficient methods for direct amidation of unactivated esters are still lacking. Here we report nickel-catalysed reductive coupling of unactivated esters with nitroarenes to furnish in one step a wide range of amides bearing functional groups relevant to the development of drugs and agrochemicals. The method has been used to expedite the syntheses of bio-active molecules and natural products, as well as their post-synthetic modifications. Preliminary mechanistic study indicates a reaction pathway distinct from conventional amidation methods using anilines as nitrogen sources. The work provides a novel and efficient method for amide synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.