ArticleThe British journal of nutrition2017
Genetic risk scores, sex and dietary factors interact to alter serum uric acid trajectory among African-American urban adults.
Article in The British journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study.BioMed research international · 2018Trial
- Sex-Specific Association of Drinking Habit and Alcohol Beverage Type With Serum Uric Acid in a Healthy Population.Journal of Korean medical science · 2026Article
- Nonlinear association of cardiometabolic index with hyperuricemia: insights from the NHANES 1999-2018 study.Frontiers in endocrinology · 2025Article
- Global, regional, and national burden of gout among older adults (≥65) from 1990 to 2021 and projections for 2050.Frontiers in public health · 2025Article
- Association between serum uric acid and triglyceride-glucose index in children and adolescents with short stature.Scientific reports · 2023Article
- Association and interaction between dietary patterns and gene polymorphisms in Liangshan residents with hyperuricemia.Scientific reports · 2022Article
- Review
- Risk Predictors of High Uric Acid Levels Among Patients with Type-2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Biochemical and Hematological Correlates of Elevated Homocysteine in National Surveys and a Longitudinal Study of Urban Adults.Nutrients · 2020Article
- Intake of selected foods and beverages and serum uric acid levels in adults: ELSA-Brasil (2008-2010).Public health nutrition · 2020Article
- Prediction model of artificial neural network for the risk of hyperuricemia incorporating dietary risk factors in a Chinese adult study.Food & nutrition research · 2020Article
- Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans.Nutrients · 2019Article
- Obesity-Related Genetic Variants and Hyperuricemia Risk in Chinese Men.Frontiers in endocrinology · 2019Article
- Dietary factors are associated with serum uric acid trajectory differentially by race among urban adults.The British journal of nutrition · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Serum uric acid (SUA), a causative agent for gout among others, is affected by both genetic and dietary factors, perhaps differentially by sex. We evaluated cross-sectional (SUAbase) and longitudinal (SUArate) associations of SUA with a genetic risk score (GRS), diet and sex. We then tested the interactive effect of GRS, diet and sex on SUA. Longitudinal data on 766 African-American urban adults participating in the Healthy Aging in Neighborhood of Diversity across the Lifespan study were used. In all, three GRS for SUA were created from known SUA-associated SNP (GRSbase (n 12 SNP), GRSrate (n 3 SNP) and GRStotal (n 15 SNP)). Dietary factors included added sugar, total alcohol, red meat, total fish, legumes, dairy products, caffeine and vitamin C. Mixed-effects linear regression models were conducted. SUAbase was higher among men compared with that among women, and increased with GRStotal tertiles. SUArate was positively associated with legume intake in women (γ=+0·14; 95 % CI +0·06, +0·22, P=0·001) and inversely related to dairy product intake in both sexes combined (γ=-0·042; 95 % CI -0·075, -0·009), P=0·010). SUAbase was directly linked to alcohol consumption among women (γ=+0·154; 95 % CI +0·046, +0·262, P=0·005). GRSrate was linearly related to SUArate only among men. Legume consumption was also positively associated with SUArate within the GRStotal's lowest tertile. Among women, a synergistic interaction was observed between GRSrate and red meat intake in association with SUArate. Among men, a synergistic interaction between low vitamin C and genetic risk was found. In sum, sex-diet, sex-gene and gene-diet interactions were detected in determining SUA. Further similar studies are needed to replicate our findings.
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