ArticleCartilage2017
Intralesional Osteophyte Regrowth Following Autologous Chondrocyte Implantation after Previous Treatment with Marrow Stimulation Technique.
Article in Cartilage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Do Nonsteroidal Anti-Inflammatory Drugs Have a Deleterious Effect on Cartilage Repair? A Systematic Review.Cartilage · 2021Pooled it
- A randomized controlled trial demonstrating sustained benefit of autologous matrix-induced chondrogenesis (AMICEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Trial
- Safety and efficacy of matrix-associated autologous chondrocyte implantation with spheroid technology is independent of spheroid dose after 4 years.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Trial
- Fixation of Osteochondral Lesions of the Knee Using Autologous Bone Pegs: Functional Evaluation of a Case Series.Revista brasileira de ortopedia · 2026Article
- [Fixation of Osteochondral Lesions of the Knee Using Autologous Bone Pegs: Functional Evaluation of a Case Series].Revista brasileira de ortopedia · 2026Article
- Subchondral bone: An emerging target for the treatment of articular surface lesions of the knee.Journal of experimental orthopaedics · 2024Review
- Long-term Assessment of Subchondral Bone Changes and Intralesional Bony Overgrowth After Third-Generation Autologous Chondrocyte Implantation: A Retrospective Study.The American journal of sports medicine · 2023Article
- MACI "Sandwich" Technique for a Large Osteochondritis Dissecans Lesion: A Case Report.Case reports in orthopedics · 2023Article
- Article
- Morphological Assessment of MACI Grafts in Patients with Revision Surgery and Total Joint Arthroplasty.Cartilage · 2021Article
- Prior Bone Marrow Stimulation Surgery Influences Outcomes After Cell-Based Cartilage Restoration: A Systematic Review and Meta-analysis.Orthopaedic journal of sports medicine · 2021Review
- Clinical and Radiographic Outcomes After Fixation of Chondral Fragments of the Knee in 6 Adolescents Using Autologous Bone Pegs.Orthopaedic journal of sports medicine · 2020Article
- Surgical osteochondral defect repair in the horse-a matter of form or function?Equine veterinary journal · 2020Review
- An Expert Consensus Statement on the Management of Large Chondral and Osteochondral Defects in the Patellofemoral Joint.Orthopaedic journal of sports medicine · 2020Article
- [Cartilage repair of the knee joint].Der Orthopade · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective Bone marrow stimulation surgeries are frequent in the treatment of cartilage lesions. Autologous chondrocyte implantation (ACI) may be performed after failed microfracture surgery. Alterations to subchondral bone as intralesional osteophytes are commonly seen after previous microfracture and removed during ACI. There have been no reports on potential recurrence. Our purpose was to evaluate the incidence of intralesional osteophyte development in 2 cohorts: existing intralesional osteophytes and without intralesional osteophytes at the time of ACI. Study Design We identified 87 patients (157 lesions) with intralesional osteophytes among a cohort of 497 ACI patients. Osteophyte regrowth was analyzed on magnetic resonance imaging and categorized as small or large (less or more than 50% of the cartilage thickness). Twenty patients (24 defects) without intralesional osteophytes at the time of ACI acted as control. Results Osteophyte regrowth was observed in 39.5% of lesions (34.4% of small osteophytes and 5.1% of large osteophytes). In subgroup analyses, regrowth was observed in 45.8% of periosteal-covered defects and in 18.9% of collagen membrane-covered defects. Large osteophyte regrowth occurred in less than 5% in either group. Periosteal defects showed a significantly higher incidence for regrowth of small osteophytes. In the control group, intralesional osteophytes developed in 16.7% of the lesions. Conclusions Even though intralesional osteophytes may regrow after removal during ACI, most of them are small. Small osteophyte regrowth occurs almost twice in periosteum-covered ACI. Large osteophytes occur only in 5% of patients. Intralesional osteophyte formation is not significantly different in preexisting intralesional osteophytes and control groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.