Evidence map›Paper›PMID 28345211›Full record

Trial reportEchocardiography (Mount Kisco, N.Y.)2017

3D echocardiographic analysis of aortic annulus for transcatheter aortic valve replacement using novel aortic valve quantification software: Comparison with computed tomography.

Anuj Mediratta, Karima Addetia, Diego Medvedofsky, Robert J Schneider, Eric Kruse, Atman P Shah, Sandeep Nathan, Jonathan D Paul, John E Blair, Takeyoshi Ota and 4 more

Abstract readComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in Echocardiography (Mount Kisco, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Observational
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anuj MedirattaSection of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Karima AddetiaSection of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Diego MedvedofskySection of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Robert J SchneiderPhilips Healthcare, Andover, MA, USA.
Eric KruseSection of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Atman P ShahSection of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Sandeep NathanSection of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Jonathan D PaulSection of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
John E BlairSection of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Takeyoshi OtaSection of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Husam H BalkhySection of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Amit R PatelSection of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.
Victor Mor-AviSection of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-7932-6473
Roberto M LangSection of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, IL, USA.

Funding

MULTIDISCIPLINARY CARDIAC SCIENCEST32HL007381 · NHLBI · UNIVERSITY OF CHICAGO · PI JEANNE M DECARA, Yoav Gilad · 1985 to 2026
$12.5M
NHLBI NIH HHS T32 HL007381
6 · The paper itself

Abstract

backgroundWith the increasing use of transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis (AS), computed tomography (CT) remains the standard for annulus sizing. However, 3D transesophageal echocardiography (TEE) has been an alternative in patients with contraindications to CT. We sought to (1) test the feasibility, accuracy, and reproducibility of prototype 3DTEE analysis software (Philips) for aortic annular measurements and (2) compare the new approach to the existing echocardiographic techniques.

methodsWe prospectively studied 52 patients who underwent gated contrast CT, procedural 3DTEE, and TAVR. 3DTEE images were analyzed using novel semi-automated software designed for 3D measurements of the aortic root, which uses multiplanar reconstruction, similar to CT analysis. Aortic annulus measurements included area, perimeter, and diameter calculations from these measurements. The results were compared to CT-derived values. Additionally, 3D echocardiographic measurements (3D planimetry and mitral valve analysis software adapted for the aortic valve) were also compared to the CT reference values.

results3DTEE image quality was sufficient in 90% of patients for aortic annulus measurements using the new software, which were in good agreement with CT (r-values: .89-.91) and small (<4%) inter-modality nonsignificant biases. Repeated measurements showed <10% measurements variability. The new 3D analysis was the more accurate and reproducible of the existing echocardiographic techniques.

conclusionsNovel semi-automated 3DTEE analysis software can accurately measure aortic annulus in patients with severe AS undergoing TAVR, in better agreement with CT than the existing methodology. Accordingly, intra-procedural TEE could potentially replace CT in patients where CT carries significant risk.

Indexed as

SoftwareAged, 80 and overAlgorithmsAortaAortic ValveAortic Valve StenosisEchocardiography, Three-DimensionalFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedMaleProsthesis FittingReproducibility of ResultsSensitivity and SpecificityTomography, X-Ray Computedaortic stenosisthree-dimensional echocardiographytranscatheter aortic valve replacement

Identifiers

PMID28345211
PMCPMC5530594

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.