ArticleScience immunology2017
Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Science immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 169 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 1 pooled it
18.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
169 citing papers in PubMed, 1 synthesis or guideline pooled it, 299 citations in OpenAlex.
- A time-resolved meta-analysis of consensus gene expression profiles during human T-cell activation.Genome biology · 2023Pooled it
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- Exploring the functions of NKG7 in CD4+ and CD8+ T cells during malaria.PLoS pathogens · 2026Article
- Dose-Dependent Alterations in Lung Immune Subpopulations in Influenza a Virus Infection.International journal of molecular sciences · 2026Article
- Expression and Role of the RNA-Binding Protein, ZFP36L1, in Mouse T Follicular Helper Cell Differentiation and Function.European journal of immunology · 2026Article
- A unified network systems approach uncovers a core program underlying T follicular helper cell differentiation.Nature communications · 2026Article
- Bayesian inference of haematopoietic stem/progenitor cell differentiation phenotypic manifolds and their bifurcation points using Gaussian processes and Gibbs sampling.Scientific reports · 2026Article
- Single-cell trajectory inference for detecting transient events in biological processes.Nucleic acids research · 2026Article
- Evaluating Batch Correction Methods for Large-Scale Mass Spectrometry Imaging of Heterogeneous Tissues.Analytical chemistry · 2026Article
- Key Concepts in Transcriptomics Data Analysis in the Era of Next-Gen Sequencing.Advances in experimental medicine and biology · 2026Review
- CycleMix: Gaussian mixture modeling of the cell cycle.Bioinformatics advances · 2026Article
- TemporalVAE: atlas-assisted temporal mapping of time-series single-cell transcriptomes during embryogenesis.Nature cell biology · 2025Article
- An interleukin-27-centered cytokine circuit regulates macrophage and T cell interactions in autoimmune diabetes.iScience · 2025Article
- A semi-supervised Bayesian approach for marker gene trajectory inference from single-cell RNA-seq data.Bioinformatics (Oxford, England) · 2025Article
- Single-cell antigen receptor sequencing in pigs with influenza.Communications biology · 2025Article
- Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection.The Journal of experimental medicine · 2025Article
- Malaria: past, present, and future.Signal transduction and targeted therapy · 2025Review
- diffGEK: differential gene expression kinetics.Bioinformatics (Oxford, England) · 2025Article
- Antibiotic-induced gut microbiome perturbation alters the immune responses to the rabies vaccine.Cell host & microbe · 2025Article
- T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses.The EMBO journal · 2025Article
109 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
23 authors at 6 institutions in 5 countries.
Tapio LönnbergEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Valentine SvenssonEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
Kylie R JamesQIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland, Australia.
Daniel Fernandez-RuizDepartment of Microbiology and Immunology, The Peter Doherty Institute, University of Melbourne, Parkville, Victoria, Australia.
Ismail SebinaQIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland, Australia.
Ruddy MontandonWellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Megan S F SoonQIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland, Australia.
Lily G FoggQIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland, Australia.
Arya Sheela NairQIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland, Australia.
Urijah LiligetoQIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland, Australia.
Michael J T StubbingtonEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Lam-Ha LyWellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Frederik Otzen BaggerEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Long Road, Cambridge, UK.
Max ZwiesseleDepartment of Computer Science, University of Sheffield, Sheffield, UK.
Neil D LawrenceDepartment of Computer Science, University of Sheffield, Sheffield, UK.
Fernando Souza-Fonseca-GuimaraesQIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland, Australia.
Patrick T BunnQIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland, Australia.
Christian R EngwerdaQIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland, Australia.
William R HeathDepartment of Microbiology and Immunology, The Peter Doherty Institute, University of Melbourne, Parkville, Victoria, Australia; The Australian Research Council Centre of Excellence in Advanced Molecular Imaging, The University of Melbourne, Parkville, Victoria, Australia.
Oliver BillkerWellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Oliver StegleEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK.
Ashraful HaqueQIMR Berghofer Medical Research Institute, Herston, Brisbane, Queensland, Australia.
Sarah A TeichmannEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
QIMR Berghofer Medical Research Institute · AUEuropean Bioinformatics Institute · GBWellcome Sanger Institute · GBUniversity of Sheffield · GBAustralian Research Council · AUPeter Doherty Institute · AU
Funding
European Research Council 260507Wellcome Trust 098051
Abstract
Differentiation of naïve CD4
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.