Trial reportScience advances2017
Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis.
Open access · goldAbstract readClinical TrialMulticenter Study
In one paragraph
Trial report in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Prediction of sepsis mortality using metabolite biomarkers in the blood: a meta-analysis of death-related pathways and prospective validation.BMC medicine · 2020Pooled it
- Assessing links between dental fluorosis and oral/systemic health via salivary microbiome in Chinese young adults.International dental journal · 2026Article
- APIP regulates the priming of canonical NLRP3 and non-canonical Caspase-11/4 inflammasomes by binding to TRAF6.Nature communications · 2025Article
- Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues.Human genomics · 2025Review
- Low blood S-methyl-5-thioadenosine is associated with postoperative delayed neurocognitive recovery.Communications biology · 2024Article
- Predictive value of laboratory indicators for in-hospital death in children with community-onset sepsis: a prospective observational study of 266 patients.BMJ paediatrics open · 2024Observational
- S-Adenosylhomocysteine Is a Useful Metabolic Factor in the Early Prediction of Septic Disease Progression and Death in Critically Ill Patients: A Prospective Cohort Study.International journal of molecular sciences · 2023Article
- Single-cell genome-wide association reveals that a nonsynonymous variant inCell genomics · 2022Article
- Article
- Patient Stratification in Sepsis: Using Metabolomics to Detect Clinical Phenotypes, Sub-Phenotypes and Therapeutic Response.Metabolites · 2022Review
- MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization.Scientific reports · 2022Article
- Altered Plasma Mitochondrial Metabolites in Persistently Symptomatic Individuals after a GBCA-Assisted MRI.Toxics · 2022Article
- SOX18-associated gene signature predicts sepsis outcome.American journal of translational research · 2022Article
- Sepsis: deriving biological meaning and clinical applications from high-dimensional data.Intensive care medicine experimental · 2021Review
- These Are the Genes You're Looking For: Finding Host Resistance Genes.Trends in microbiology · 2021Review
- Plasma Metabolomics Reveals Pathogenesis of Retained Placenta in Dairy Cows.Frontiers in veterinary science · 2021Article
- Modeling of variables in cellular infection reveals CXCL10 levels are regulated by human genetic variation and the Chlamydia-encoded CPAF protease.Scientific reports · 2020Article
- Transcriptomic study of lipopolysaccharide-induced sepsis damage in a mouse heart model.Experimental and therapeutic medicine · 2020Article
- Investigation of the IL-1β +3954 C>T polymorphism and the risk of sepsis: A case-control study.Medicine · 2020Article
- Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer's disease.Brain, behavior, and immunity · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 6 institutions in 3 countries.
Liuyang WangDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.ORCID 0000-0001-9556-2361
Emily R KoDuke Regional Hospital, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA.; Duke Center for Applied Genomics & Precision Medicine, Department of Medicine, School of Medicine, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-9438-1566
James J GilchristWellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford OX3 7BN, U.K.; Department of Paediatrics, University of Oxford, Oxford OX3 9DU, U.K.
Kelly J PittmanDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.ORCID 0000-0003-1580-7889
Anna RautanenWellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford OX3 7BN, U.K.
Matti PirinenWellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford OX3 7BN, U.K.
J Will ThompsonProteomics and Metabolomics Core Facility, Duke University Medical Center, Durham, NC 27710, USA.
Laura G DuboisProteomics and Metabolomics Core Facility, Duke University Medical Center, Durham, NC 27710, USA.
Raymond J LangleyDepartment of Pharmacology and Center for Lung Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA.ORCID 0000-0001-8849-9325
Sarah L JaslowDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.ORCID 0000-0002-9554-3117
Raul E SalinasDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.
D Clayburn RouseDivision of Laboratory Animal Resources, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0001-5945-3504
M Arthur MoseleyDuke Center for Applied Genomics & Precision Medicine, Department of Medicine, School of Medicine, Duke University, Durham, NC 27708, USA.; Proteomics and Metabolomics Core Facility, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0001-9907-738X
Salim MwarumbaKenya Medical Research Institute-Wellcome Trust Clinical Research Programme, Kilifi 80108, Kenya.
Patricia NjugunaKenya Medical Research Institute-Wellcome Trust Clinical Research Programme, Kilifi 80108, Kenya.
Neema MturiKenya Medical Research Institute-Wellcome Trust Clinical Research Programme, Kilifi 80108, Kenya.
Wellcome Trust Case Control Consortium 2
Kenyan Bacteraemia Study Group
Thomas N WilliamsKenya Medical Research Institute-Wellcome Trust Clinical Research Programme, Kilifi 80108, Kenya.; Department of Medicine, Imperial College, Norfolk Place, London W2 1PG, U.K.ORCID 0000-0003-4456-2382
J Anthony G ScottKenya Medical Research Institute-Wellcome Trust Clinical Research Programme, Kilifi 80108, Kenya.; Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, U.K.ORCID 0000-0001-7533-5006
Adrian V S HillWellcome Trust Centre for Human Genetics, Roosevelt Drive, University of Oxford, Oxford OX3 7BN, U.K.; Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, U.K.
Christopher W WoodsDuke Center for Applied Genomics & Precision Medicine, Department of Medicine, School of Medicine, Duke University, Durham, NC 27708, USA.; Division of Infectious Diseases and International Health, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA.; Medical Service, Durham Veterans Affairs Health Care System, Durham, NC 27705, USA.ORCID 0000-0001-7240-2453
Geoffrey S GinsburgDuke Center for Applied Genomics & Precision Medicine, Department of Medicine, School of Medicine, Duke University, Durham, NC 27708, USA.
Ephraim L TsalikDuke Center for Applied Genomics & Precision Medicine, Department of Medicine, School of Medicine, Duke University, Durham, NC 27708, USA.; Division of Infectious Diseases and International Health, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA.; Emergency Medicine Service, Durham Veterans Affairs Health Care System, Durham, NC 27705, USA.ORCID 0000-0002-6417-2042
Dennis C KoDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710, USA.; Division of Infectious Diseases and International Health, Department of Medicine, School of Medicine, Duke University, Durham, NC 27710, USA.
Duke University · USCentre for Human Genetics · GBKenya Medical Research Institute · KEDuke Medical Center · USUniversity of London · GBUniversity of South Alabama · US
Funding
Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3MHUMAN GENETIC VARIATION REGULATING SALMONELLA HOST-PATHOGEN INTERACTIONS AND DISEASE SUSCEPTIBILITYR01AI118903 · NIAID · DUKE UNIVERSITY · PI KO, DENNIS CHUN-YONE · 2015 to 2024
$4.2MNCATS NIH HHS UL1 TR001117NIAID NIH HHS R01 AI118903Wellcome Trust
Abstract
Sepsis is a deleterious inflammatory response to infection with high mortality. Reliable sepsis biomarkers could improve diagnosis, prognosis, and treatment. Integration of human genetics, patient metabolite and cytokine measurements, and testing in a mouse model demonstrate that the methionine salvage pathway is a regulator of sepsis that can accurately predict prognosis in patients. Pathway-based genome-wide association analysis of nontyphoidal
Indexed as
AdenosineModels, BiologicalPolymorphism, Single NucleotideSalmonellaSalmonella InfectionsSepsisAdolescentBiomarkersFemaleGenome-Wide Association StudyHuman GeneticsHumansMachine LearningMaleAdenosineBiomarkersAPIPbiomarkercytokineinflammationmethionine salvagemethylthioadenosinepyroptosisSalmonellasepsisSIRS
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.