ArticleScience advances2017
Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module.
Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 253 papers.
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The trial behind it
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Who cites it
253 citing papers in PubMed.
- Advances and perspectives in genetically encoded biosensors for biomarker detection and theranostic circuits.Synthetic and systems biotechnology · 2027Review
- Metal-organic framework-based wearable electrochemical glucose sensors for sweat analysis: materials design, sensing mechanisms, and future perspectives.RSC advances · 2026Review
- Three-Dimensional Interconnect Technologies for Advanced Flexible Electronics.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Applications of Wearable Sweat Biosensors in Sports Activities with Real-World Cases.Bioengineering (Basel, Switzerland) · 2026Review
- A Portable and Dual-Button Microneedle Device Enables Intelligent Multimodal Laser Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Flexible Multimodal Wearable Biosensors for Continuous Health Monitoring: Recent Advances and Challenges.Biosensors · 2026Review
- Seamless human electronics interfacing through advanced skin attachable and implantable sensor technologies.Discover nano · 2026Review
- Sweat as a diagnostic biofluid: analytical advances and future directions.Journal of pharmaceutical analysis · 2026Review
- Flexible biodegradable wireless battery-free integrated theranostic adhesive patch.Bioactive materials · 2026Article
- Development of Laser-Scribed Graphene Electrodes for Label-Free L-Histidine Sensing in Artificial Sweat.Biosensors · 2026Article
- Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Challenges of Wearable Biosensors and Ways to Overcome Them.Biosensors · 2026Review
- The role of metformin in extracellular matrix-based three-dimensional cell culture Models: A mini-review on therapeutic potentials.Biochemistry and biophysics reports · 2026Review
- Wearable Sensors for Health Monitoring.Biosensors · 2026Review
- An All-Soft Wearable Electrochemiluminescence Chip for Sweat Metabolite Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Portable and label-free optical detection of sweat glucose using functionalized plasmonic nanopillar array.Microsystems & nanoengineering · 2026Article
- Article
- Soft bioelectronics for wireless drug delivery: programmable, minimally invasive and closed-loop therapeutics.npj soft matter · 2026Review
- Organic Electrochemical Transistors in Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Body Biofluids for Minimally-Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential.Advanced healthcare materials · 2026Review
193 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enzyme when exposed to mechanical friction and skin deformation. Precise point-of-care therapy in response to the measured glucose levels is still very challenging. We present a wearable/disposable sweat-based glucose monitoring device integrated with a feedback transdermal drug delivery module. Careful multilayer patch design and miniaturization of sensors increase the efficiency of the sweat collection and sensing process. Multimodal glucose sensing, as well as its real-time correction based on pH, temperature, and humidity measurements, maximizes the accuracy of the sensing. The minimal layout design of the same sensors also enables a strip-type disposable device. Drugs for the feedback transdermal therapy are loaded on two different temperature-responsive phase change nanoparticles. These nanoparticles are embedded in hyaluronic acid hydrogel microneedles, which are additionally coated with phase change materials. This enables multistage, spatially patterned, and precisely controlled drug release in response to the patient's glucose level. The system provides a novel closed-loop solution for the noninvasive sweat-based management of diabetes mellitus.
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