Evidence map›Paper›PMID 28345028›Full record

ArticleScience advances2017

Self-powered integrated microfluidic point-of-care low-cost enabling (SIMPLE) chip.

Erh-Chia Yeh, Chi-Cheng Fu, Lucy Hu, Rohan Thakur, Jeffrey Feng, Luke P Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Droplet Digital CRISPR for Nucleic Acid Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Advances in methods for rapid detection of Staphylococcus aureus and methicillin-resistant S. aureus.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Erh-Chia YehDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.; Berkeley Sensor and Actuator Center, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-0902-2954
Chi-Cheng FuDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.; Berkeley Sensor and Actuator Center, University of California, Berkeley, Berkeley, CA 94720, USA.
Lucy HuDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.
Rohan ThakurDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.
Jeffrey FengDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.
Luke P LeeDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.; Berkeley Sensor and Actuator Center, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA 94720, USA.; Biophysics Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Portable, low-cost, and quantitative nucleic acid detection is desirable for point-of-care diagnostics; however, current polymerase chain reaction testing often requires time-consuming multiple steps and costly equipment. We report an integrated microfluidic diagnostic device capable of on-site quantitative nucleic acid detection directly from the blood without separate sample preparation steps. First, we prepatterned the amplification initiator [magnesium acetate (MgOAc)] on the chip to enable digital nucleic acid amplification. Second, a simplified sample preparation step is demonstrated, where the plasma is separated autonomously into 224 microwells (100 nl per well) without any hemolysis. Furthermore, self-powered microfluidic pumping without any external pumps, controllers, or power sources is accomplished by an integrated vacuum battery on the chip. This simple chip allows rapid quantitative digital nucleic acid detection directly from human blood samples (10 to 10

Indexed as

Lab-On-A-Chip DevicesMethicillin-Resistant Staphylococcus aureusPoint-of-Care SystemsDNA, BacterialHumansMicrofluidic Analytical TechniquesDNA, Bacterialdigital medicinedigital PCRisothermal amplificationmicrofluidic patterningMicrofluidicsplasma separationpoint-of-care molecular diagnosticsprecision medicinerecombinase polymerase amplificationsample preparation

Identifiers

PMID28345028
PMCPMC5362183

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.