ArticleAlzheimer's & dementia (New York, N. Y.)2016
Proof of concept demonstration of optimal composite MRI endpoints for clinical trials.
Article in Alzheimer's & dementia (New York, N. Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04946149 (Psychosocial Factors, Lifestyle and Central Pain Processing as Potential Predictors of Outcome After Rehabilitation for Rotator Cuff Repair), which is not on this map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Psychosocial Factors, Lifestyle and Central Pain Processing as Potential Predictors of Outcome After Rehabilitation for Rotator Cuff Repair: A Study Design for a Prospective Longitudinal Cohort Study
Who cites it
10 citing papers in PubMed.
- Optimal Weighting of Preclinical Alzheimer's Cognitive Composite (PACC) Scales to Improve their Performance as Outcome Measures for Alzheimer's Disease Clinical Trials.International journal of statistics in medical research · 2023Article
- Association of Regional Cortical Network Atrophy With Progression to Dementia in Patients With Primary Progressive Aphasia.Neurology · 2023Article
- Neuroimaging in Frontotemporal Lobar Degeneration: Research and Clinical Utility.Advances in experimental medicine and biology · 2021Review
- Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET.Science translational medicine · 2020Observational
- Clinical and cortical decline in the aphasic variant of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
- Sex-specific composite scales for longitudinal studies of incipient Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.) · 2019Article
- Potential implications of practice effects in Alzheimer's disease prevention trials.Alzheimer's & dementia (New York, N. Y.) · 2017Article
- Power analysis to detect treatment effects in longitudinal clinical trials for Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.) · 2017Article
- Design of pilot studies to inform the construction of composite outcome measures.Alzheimer's & dementia (New York, N. Y.) · 2017Article
- Implications of practice effects for the design of Alzheimer clinical trials.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundAtrophy measures derived from structural MRI are promising outcome measures for early phase clinical trials, especially for rare diseases such as primary progressive aphasia (PPA), where the small available subject pool limits our ability to perform meaningfully powered trials with traditional cognitive and functional outcome measures.
methodsWe investigated a composite atrophy index in 26 PPA participants with longitudinal MRIs separated by two years. Rogalski
resultsThe optimal composite endpoint required 38% fewer subjects to detect the same percent slowing in atrophy than required by the left PSTC endpoint.
conclusionsOptimal composites can increase the power of clinical trials and increase the probability that smaller trials are informative, an observation especially relevant for PPA, but also for related neurodegenerative disorders including Alzheimer's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.