Evidence map›Paper›PMID 28344829›Full record

ArticleFuture science OA2017

Systemic angiopoietin-1/2 dysregulation following cardiopulmonary bypass in adults.

Emmanuel Charbonney, Elizabeth Wilcox, Yuexin Shan, Pablo Perez d'Empaire, Abhijit Duggal, Gordon D Rubenfeld, Conrad Liles, Claudia Dos Santos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Emmanuel CharbonneyCentre de Recherche de l'Hôpital du Sacré-Coeur, University of Montreal, 5400 Boulevard Gouin Ouest, Montréal, QC H4J 1C5, Canada; Centre de Recherche de l'Hôpital du Sacré-Coeur, University of Montreal, 5400 Boulevard Gouin Ouest, Montréal, QC H4J 1C5, Canada.
Elizabeth WilcoxInterdepartmental Division of Critical Care, University of Toronto, University Health Network, 399 Bathurst St, Toronto, ON M5T 2S8, Canada; Interdepartmental Division of Critical Care, University of Toronto, University Health Network, 399 Bathurst St, Toronto, ON M5T 2S8, Canada.
Yuexin ShanKeenan Research Centre of Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON M5B 1W8, Canada; Keenan Research Centre of Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON M5B 1W8, Canada.
Pablo Perez d'EmpaireDepartment of Anesthesia, University of Toronto 12th Floor, 123 Edward Street, Toronto, ON M5G 1E2, Canada; Department of Anesthesia, University of Toronto 12th Floor, 123 Edward Street, Toronto, ON M5G 1E2, Canada.
Abhijit DuggalDepartment of Pulmonary, Allergy, & Critical Care, Respiratory Institute, Cleveland Clinic Main Campus, 9500 Euclid Avenue, Cleveland, OH 44195, USA; Department of Pulmonary, Allergy, & Critical Care, Respiratory Institute, Cleveland Clinic Main Campus, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Gordon D RubenfeldInterdepartmental Division of Critical Care, University of Toronto, Trauma, Emergency & Critical Care Program, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada; Interdepartmental Division of Critical Care, University of Toronto, Trauma, Emergency & Critical Care Program, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada.
Conrad LilesDepartment of Medicine, University of Washington, 1959 NE Pacific St. Box 356420, Seattle, WA 98195, USA; Department of Medicine, University of Washington, 1959 NE Pacific St. Box 356420, Seattle, WA 98195, USA.
Claudia Dos SantosInterdepartmental Division of Critical Care, University of Toronto, St. Michael's Hospital-Keenan Research Centre of Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON M5B 1W8, Canada; Interdepartmental Division of Critical Care, University of Toronto, St. Michael's Hospital-Keenan Research Centre of Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON M5B 1W8, Canada.
University of Toronto · CACleveland Clinic · USHealth Sciences Centre · CAUniversité de Montréal · CAUniversity Health Network · CAUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimVascular leakage following cardiopulmonary bypass contributes to morbidity. Angiopoietin-1 and -2 are biomarkers of endothelial dysfunction. Our aim was to characterize Ang-1 and -2 association with clinical characteristics and outcomes.

methodsObservational cohort study measuring Ang-1/-2 with a panel of cytokines in adults undergoing cardiopulmonary bypass.

resultsAng-2 levels increased immediately postop whereas Ang-1 levels decreased over time. No significant correlation was found with other inflammatory mediators. High correlation was found between the hospital length of stay and Ang-2 increase at 24 h (rho = 0.590; p < 0.0001). The predictors of Ang-2 increase were female gender, cross clamp time, transfusion of blood and absence of angiotensin-converting enzyme inhibitor as a pre-op medication.

conclusionAngiopoietins can detect vascular leakage early and could impact patient's management to decrease length of stay after cardiac surgery.

Indexed as

angiopoietinbiomarkercardiac surgerycardiopulmonary bypasslength of stayvascular leakagevascular permeability

Identifiers

PMID28344829
PMCPMC5351704
OpenAlexW2576008643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.