Evidence map›Paper›PMID 28344826›Full record

ArticleFuture science OA2017

Impact of bone marrow-derived mesenchymal stem cells on remodeling the lung injury induced by lipopolysaccharides in mice.

Mouchira M Mohi El-Din, Laila A Rashed, Mohi A Mahmoud Haridy, Atef Mohamed Khalil, Mohamed A Mohamed Albadry

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mouchira M Mohi El-DinPathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
Laila A RashedBiochemistry & Molecular Biology Department, Medicine Faculty, Cairo University, Cairo, Egypt; Biochemistry & Molecular Biology Department, Medicine Faculty, Cairo University, Cairo, Egypt.
Mohi A Mahmoud HaridyPathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
Atef Mohamed KhalilPathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
Mohamed A Mohamed AlbadryPathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt; Pathology & Clinical Pathology Department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.
South Valley University · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study evaluated the potential of bone marrow derived mesenchymal stem cells (MSCs) to regulate cytokines and remodel the lung induced by lipopolysaccharide (LPS; O-antigen). MATERIALS &

methodsA group of mice (n = 21) was inoculated intraperitoneally with one dose 0.1 ml containing 0.025 mg LPS/mouse, and another treated intravenously with one dose of labeling bone marrow derived MSCs at 7.5 × 10

resultsMSCs increased the level of IL-10 with suppression of TNF-α, decrease of collagen fibers and renewal of alveolar type I cells, together with lung tissue remodeling.

conclusionMSCs were shown to modulate inflammatory cytokines (TNF-α and IL-10) and to differentiate into alveolar type I cells, which prevented fibrosis in lung tissue from LPS-treated mice.

Indexed as

cytokinesflow cytometryfluorescent techniquehistopathologyimmunohistochemistrylipolysaccharidelungsmesenchymal stem cellsmice

Identifiers

PMID28344826
PMCPMC5351512
OpenAlexW2575784303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.