ArticleBMC obesity2017
Urinary biomarkers as indicator of chronic inflammation and endothelial dysfunction in obese adolescents.
Article in BMC obesity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Endothelial Peripheral Arterial Tonometry (Endo-PAT 2000) use in paediatric patients: a systematic review.BMJ open · 2023Pooled it
- Urinary Biomarkers for Radiation Cystitis: Current Insights and Future Directions.International journal of molecular sciences · 2026Review
- Uric acid mediates the association of alpha-1 acid glycoprotein with gallstones in adult women in the United States.Scientific reports · 2025Article
- Involvement of circulating microRNAs in the pathogenesis of atherosclerosis in young patients with obesity.Physiological research · 2024Article
- Noninvasive, Multimodal Inflammatory Biomarker Discovery for Systemic Inflammation (NOVA Study): Protocol for a Cross-Sectional Study.JMIR research protocols · 2024Article
- Adolescent obesity and short sleep duration as independent risk factors for hypertension: a population-based cohort study.Journal of human hypertension · 2024Article
- Tumor Necrosis Factor (TNF) α, Endothelin (ET) 1 and α1-Acid Glycoprotein (AGP) as Potential Urine and Serum Markers of Metabolic Complications in Psoriasis?Dermatology and therapy · 2023Article
- Article
- Serum levels of vitamin D, retinol, zinc, and CRP in relation to obesity among children and adolescents.European journal of medical research · 2022Article
- Endothelial impairment evaluation by peripheral arterial tonometry in pediatric endocrinopathies: A narrative review.World journal of diabetes · 2021Review
- Augmented transcripts of kidney injury markers and renin angiotensin system in urine samples of overweight young adults.Scientific reports · 2020Article
- Effect of Morning vs. Evening Turmeric Consumption on Urine Oxidative Stress Biomarkers in Obese, Middle-Aged Adults: A Feasibility Study.International journal of environmental research and public health · 2020Article
- Arterial Stiffness and Endothelial Function in Young Obese Patients - Vascular Resistance Matters.Journal of atherosclerosis and thrombosis · 2019Article
- Racial differences in myocardial deformation in obese children: Significance of inflammatory state.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2019Article
- Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an "evolutionary bloom".Human genomics · 2019Review
- Urinary Biomarkers of Inflammation and Oxidative Stress Are Elevated in Obese Children and Correlate with a Marker of Endothelial Dysfunction.Oxidative medicine and cellular longevity · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is a pro-inflammatory state that may predispose patients to acute coronary syndrome characterized by chronic low grade inflammation resulting in endothelial dysfunction (ED). The aim of the study was to evaluate urinary biomarkers of inflammation and ED in adolescents with obesity.
methodsSixty three subjects were recruited for the study. Twenty healthy adolescents with normal body mass (NW), 14 overweight (OW), 29 obese (OA) subjects were selected. An EndoPat 2000 device was used to measure the reactive hyperemia index (RHI). First morning fasting urine samples were tested for interleukin 6 (IL-6), endothelin 1 (ET-1), alpha-1-acid glycoprotein (AGP), tumor necrosis factor- α (TNF-α) and corrected to urinary creatinine.
resultsUrinary TNF-α was significantly higher in OA group (52.4 ± 15.3 pg/mg) compared to adolescents with NW (14.1 ± 1.2 pg/mg,
conclusionUrinary TNF-alpha is significantly elevated in obese adolescents and correlates with urinary ET-1, which is recognized as a biomarker for endothelial dysfunction. Since obesity is a chronic inflammatory state, elevated urinary TNF-alpha might be used as a non invasive tool to monitor the level of that inflammation.
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