Evidence map›Paper›PMID 28344788›Full record

ArticleUnited European gastroenterology journal2017

Lymphoma development and survival in refractory coeliac disease type II: Histological response as prognostic factor.

P Nijeboer, Rlj van Wanrooij, T van Gils, N J Wierdsma, G J Tack, B I Witte, H J Bontkes, O Visser, Cjj Mulder, G Bouma

Open access · bronzeAbstract read
In one paragraph

Article in United European gastroenterology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Guideline
  2. Refractory Celiac Disease: What the Gastroenterologist Should Know.International journal of molecular sciences · 2024
    Review
  3. Review
  4. Celiac Disease Revisited.GE Portuguese journal of gastroenterology · 2022
    Review
  5. Association between intestinal neoplasms and celiac disease: A review.World journal of gastrointestinal oncology · 2021
    Review
  6. Article
  7. Refractory Celiac Disease.Current gastroenterology reports · 2020
    Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

P NijeboerDepartment of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands.
Rlj van WanrooijDepartment of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands.
T van GilsDepartment of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands.
N J WierdsmaDepartment of Nutrition and Dietetics, VU University Medical Centre, Amsterdam, The Netherlands.
G J TackDepartment of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands.
B I WitteDepartment of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands.
H J BontkesDepartment of Pathology, VU University Medical Centre, Amsterdam, The Netherlands.
O VisserDepartment of Haematology, VU University Medical Centre, Amsterdam, The Netherlands.
Cjj MulderDepartment of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands.
G BoumaDepartment of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands.
Amsterdam UMC Location Vrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRefractory coeliac disease type II (RCDII) frequently transforms into an enteropathy-associated T-cell lymphoma (EATL) and therefore requires intensive treatment. Current evaluated treatment strategies for RCDII include cladribine (2-CdA) and autologous stem cell transplantation (auSCT).

objectiveThe purpose of this study was to evaluate long-term survival and define clear prognostic criteria for EATL development comparing two treatment strategies.

methodsA total of 45 patients were retrospectively analysed. All patients received 2-CdA, after which they were either closely monitored (monotherapy,

resultsTen patients (22%) ultimately developed EATL; nine of these had received monotherapy. Absence of histological remission after monotherapy was associated with EATL development (

conclusionHistological response is an accurate parameter to evaluate the effect of 2-CdA therapy and this parameter should be leading in the decisions whether or not to perform a step-up treatment approach in RCDII.

Indexed as

autologous stem cell transplantationcladribinecoeliac diseasecomplicated coeliac diseaseenteropathy-associated T-cell lymphomaRefractory coeliac disease type II

Identifiers

PMID28344788
PMCPMC5349358
OpenAlexW2342614050

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.