Evidence map›Paper›PMID 28344782›Full record

ArticleCilia2017

La-related protein 6 controls ciliated cell differentiation.

Zarko Manojlovic, Ryan Earwood, Akiko Kato, Diana Perez, Oscar A Cabrera, Ruth Didier, Timothy L Megraw, Branko Stefanovic, Yoichi Kato

Open access · hybridAbstract read
In one paragraph

Article in Cilia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. The LARP6 La module fromRNA biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zarko ManojlovicDepartment of Biomedical Sciences, Florida State University College of Medicine, 1115W. Call Street, Tallahassee, FL 32306-4300 USA.
Ryan EarwoodDepartment of Biomedical Sciences, Florida State University College of Medicine, 1115W. Call Street, Tallahassee, FL 32306-4300 USA.
Akiko KatoDepartment of Biomedical Sciences, Florida State University College of Medicine, 1115W. Call Street, Tallahassee, FL 32306-4300 USA.
Diana PerezDepartment of Biomedical Sciences, Florida State University College of Medicine, 1115W. Call Street, Tallahassee, FL 32306-4300 USA.
Oscar A CabreraDepartment of Biomedical Sciences, Florida State University College of Medicine, 1115W. Call Street, Tallahassee, FL 32306-4300 USA.
Ruth DidierDepartment of Biomedical Sciences, Florida State University College of Medicine, 1115W. Call Street, Tallahassee, FL 32306-4300 USA.
Timothy L MegrawDepartment of Biomedical Sciences, Florida State University College of Medicine, 1115W. Call Street, Tallahassee, FL 32306-4300 USA.
Branko StefanovicDepartment of Biomedical Sciences, Florida State University College of Medicine, 1115W. Call Street, Tallahassee, FL 32306-4300 USA.
Yoichi KatoDepartment of Biomedical Sciences, Florida State University College of Medicine, 1115W. Call Street, Tallahassee, FL 32306-4300 USA.
Florida State University · US

Funding

Novel regulator of Notch signaling in determination of left-right asymmetry durinR15GM087641 · NIGMS · FLORIDA STATE UNIVERSITY · PI KATO, YOICHI · 2010 to 2010
$213k
NIGMS NIH HHS R15 GM087641
6 · The paper itself

Abstract

backgroundLa-related protein 6 (LARP6) is an evolutionally conserved RNA-binding protein. Vertebrate LARP6 binds the 5' stem-loop found in mRNAs encoding type I collagen to regulate their translation, but other target mRNAs and additional functions for LARP6 are unknown. The aim of this study was to elucidate an additional function of LARP6 and to evaluate the importance of its function during development.

methodsTo uncover the role of LARP6 in development, we utilized Morpholino Oligos to deplete LARP6 protein in

resultsWe knocked down LARP6 in

conclusionsLa-related protein 6 is involved in ciliated cell differentiation during development by controlling the expression of cilia-related genes including

Indexed as

CiliaLARP6mcidasXenopus

Identifiers

PMID28344782
PMCPMC5364628
OpenAlexW2600165955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.