ArticleWorld journal of gastrointestinal oncology2017
Heavily calcified gastrointestinal stromal tumors: Pathophysiology and implications of a rare clinicopathologic entity.
Article in World journal of gastrointestinal oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Gastric Calcifying Fibrous Tumor: An Easy Misdiagnosis as Gastrointestinal Stromal Tumor-A Systemic Review.Medicina (Kaunas, Lithuania) · 2020Pooled it
- Computed tomography features of a primary extragastrointestinal stromal tumor of the lesser omentum with spontaneous calcification in a young adult: A case report.Radiology case reports · 2026Article
- A scoring model for differentiating gastric calcifying fibrous tumors from gastrointestinal stromal tumors less than 2 cm based on CT features.BMC medical imaging · 2026Article
- A large non-inverted true diverticulum resembling a submucosal tumor of the ascending colon: a report of a rare case.Clinical journal of gastroenterology · 2025Article
- Association between calcification and risk stratification in gastric gastrointestinal stromal tumors.Abdominal radiology (New York) · 2025Article
- Multifocal gastrointestinal stromal tumor with osseous metaplasia: a case report.Journal of medical case reports · 2023Article
- A case of spontaneous mesenteric hematoma with diagnostic difficulty.Surgical case reports · 2020Article
- Detection of esophageal and glandular stomach calcification in cow (Veterinary world · 2020Article
- Calcified mucinous adenocarcinoma of the stomach metastatic to the iris: a case report.Journal of medical case reports · 2019Article
- Gastric gastrointestinal stromal tumor with osseous differentiation and stromal calcification: A case report and review of literature.SAGE open medical case reports · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, and are characterized by a broad spectrum of clinical, histological and molecular features at presentation. Although focal and scattered calcifications are not uncommon within the primary tumor mass, heavy calcification within a GIST is rarely described in the literature and the clinical-biological meaning of this feature remains unclear. Cases with such an atypical presentation are challenging and may be associated with diagnostic pitfalls. Herein, we report a gastric GIST with the unusual presentation of prominent calcifications that was identified incidentally on imaging during a post-trauma diagnostic work-up. The patient underwent laparoscopic surgery with a radical resection of the mass, which was subsequently characterized by histological analysis as spindle-shaped tumor cells, positive for CD117/c-KIT, CD34 and DOG1, and with calcified areas. Given the intermediate risk of recurrence, no adjuvant therapy was recommended and the patient underwent regular follow-up for 22 mo, with no evidence of relapse. Our case can be considered of interest because of the rarity of clinical presentation and the uniquely large size of the GIST at diagnosis (longest diameter exceeding 9 cm). In closing, we discuss the pathophysiology and clinical implications of calcifications in GISTs by reviewing the most up-to-date relevant literature.
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