ReviewTherapeutic advances in musculoskeletal disease2017
Diabetes and bone health: latest evidence and clinical implications.
Review in Therapeutic advances in musculoskeletal disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The trial behind it
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Who cites it
52 citing papers in PubMed.
- Circulating Gut Microbiota Metabolite Trimethylamine N-Oxide (TMAO) and Changes in Bone Density in Response to Weight Loss Diets: The POUNDS Lost Trial.Diabetes care · 2019Trial
- Relationships Among Adipose Tissue Distribution, Vitamin D, and Bone Metabolism in Normoglycemic and Type 2 Diabetic Individuals.Metabolites · 2026Article
- Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Radiomorphometric and texture-based mandibular bone assessment in type 2 diabetes mellitus: correlation with vitamin D, osteocalcin, and glycemic control-an analytical cross-sectional study.Scientific reports · 2026Article
- Observational
- Osteoporosis After Menopause and After Drug Therapy: The Molecular Mechanism of Bone Loss and Its Treatment.International journal of molecular sciences · 2026Review
- Relative comparison of spinal deformity between pediatric high-impact and geriatric low-impact fractures.Surgical neurology international · 2026Article
- Gut microbiota-derived TMAO drives the kidney-bone-vascular axis in chronic kidney disease complications.Renal failure · 2025Review
- Bone Health and Osteoporosis Management in the Elderly: A Review of Guidelines and Orthopedic Implications.Cureus · 2025Review
- The relationship between type 2 diabetes mellitus, prediabetes, and bone mineral density in middle-aged and older adults: a nationwide study.Archives of osteoporosis · 2025Article
- The Effect of Diabetes Mellitus on Mandibular Growth.Turkish journal of orthodontics · 2025Article
- The Alterations in the Osteoimmune Microenvironment of STZ-Induced Type 2 Diabetic Mice:A Single-Cell RNA Sequencing Analysis.Journal of inflammation research · 2025Article
- Effect of Fibroblast Growth Factor (FGF) 19 and 21 on Hip Geometry and Strength in Post-menopausal Osteoporosis (PMO).Calcified tissue international · 2024Article
- Bone microarchitecture and strength assessed by HRpQCT in individuals with type 2 diabetes and prediabetes: the Maastricht study.JBMR plus · 2024Article
- The single point insulin sensitivity estimator (SPISE) is associated with bone health in Arab adults.Aging clinical and experimental research · 2024Article
- Plasma undercarboxylated osteocalcin dynamics with glycemic stress reflects insulin sensitivity and beta-cell function in humans with and without T2DM.Metabolism open · 2023Article
- Diabetic microvascular disease in non-classical beds: the hidden impact beyond the retina, the kidney, and the peripheral nerves.Cardiovascular diabetology · 2023Review
- Effects of metabolic syndrome on bone mineral density in postmenopausal Turkish women.African health sciences · 2023Article
- Skeletal manifestations in a streptozotocin-induced C57BL/6 model of Type 1 diabetes.Bone reports · 2022Article
- Quantitative CT for Preoperative Assessment of Lumbar Degenerative Spondylolisthesis: The Unique Impact of L4 Bone Mineral Density on Single-Level Disease.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the prevalence of diabetes is increasing worldwide, research on some of the lesser-known effects, including impaired bone health, are gaining a lot of attention. The two most common forms of diabetes are type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). These two differ in their physiology, with T1DM stemming from an inability to produce insulin, and T2DM involving an insufficient response to the insulin that is produced. This review aims to highlight the most current information regarding diabetes as it relates to bone health. It looks at biochemical changes that characterize diabetic bone; notably increased adiposity, altered bone metabolism, and variations in bone mineral density (BMD). Then several hypotheses are analyzed, concerning how these changes may be detrimental to the highly orchestrated processes that are involved in bone formation and turnover, and ultimately result in the distinguishing features of diabetic bone. The review proceeds by explaining the effects of antidiabetes medications on bone health, then highlighting several ways that diabetes can play a part in other clinical treatment outcomes. With diabetes negatively affecting bone health and creating other clinical problems, and its treatment options potentiating these effects, physicians should consider the use of anti-osteoporotic drugs to supplement standard anti-diabetes medications in patients suffering with diabetic bone loss.
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