ArticleMikrochimica acta2017
The interaction of fluorescent nanodiamond probes with cellular media.
Article in Mikrochimica acta, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Diamond Nanoparticles Suppress Migration of T98G Glioblastoma Cells by Targeting ECM-Integrin Interactions and Intracellular Signaling, Leading to Extensive Proteome Alterations.Nanotechnology, science and applications · 2025Article
- High-precision chemical quantum sensing in flowing monodisperse microdroplets.Science advances · 2024Article
- Multimodal analysis of traction forces and the temperature dynamics of living cells with a diamond-embedded substrate.Biomedical optics express · 2024Article
- Cell-particles interaction - selective uptake and transport of microdiamonds.Communications biology · 2024Article
- Timing and Mechanisms of Nanodiamond Uptake in Colon Cancer Cells.Nanotechnology, science and applications · 2024Article
- Diamond Relaxometry as a Tool to Investigate the Free Radical Dialogue between Macrophages and Bacteria.ACS nano · 2023Article
- Interaction between Nanoparticles, Membranes and Proteins: A Surface Plasmon Resonance Study.International journal of molecular sciences · 2022Article
- Recent Development of Fluorescent Nanodiamonds for Optical Biosensing and Disease Diagnosis.Biosensors · 2022Review
- Intracellular Quantum Sensing of Free-Radical Generation Induced by Acetaminophen (APAP) in the Cytosol, in Mitochondria and the Nucleus of Macrophages.ACS sensors · 2022Article
- Increasing the effect of annonacin using nanodiamonds to inhibit breast cancer cells growth in rats (Heliyon · 2022Article
- Use of curcumin-modified diamond nanoparticles in cellular imaging and the distinct ratiometric detection of MgNanoscale advances · 2021Article
- pH Sensitive Dextran Coated Fluorescent Nanodiamonds as a Biomarker for HeLa Cells Endocytic Pathway and Increased Cellular Uptake.Nanomaterials (Basel, Switzerland) · 2021Article
- Diamond Nanoparticles-Porphyrin mTHPP Conjugate as Photosensitizing Platform: Cytotoxicity and Antibacterial Activity.Nanomaterials (Basel, Switzerland) · 2021Article
- Plasma & Microwaves as Greener Options for Nanodiamond Purification: Insight Into Cytocompatibility.Frontiers in bioengineering and biotechnology · 2021Article
- Nanodiamond Relaxometry-Based Detection of Free-Radical Species When Produced in Chemical Reactions in Biologically Relevant Conditions.ACS sensors · 2020Article
- Targeting Nanodiamonds to the Nucleus in Yeast Cells.Nanomaterials (Basel, Switzerland) · 2020Article
- Delivery of siRNA to Ewing Sarcoma Tumor Xenografted on Mice, Using Hydrogenated Detonation Nanodiamonds: Treatment Efficacy and Tissue Distribution.Nanomaterials (Basel, Switzerland) · 2020Article
- Micro Versus Macro - The Effect of Environmental Confinement on Cellular Nanoparticle Uptake.Frontiers in bioengineering and biotechnology · 2020Article
- Why nanodiamond carriers manage to overcome drug resistance in cancer.Cancer drug resistance (Alhambra, Calif.) · 2020Review
- Nanodiamond for Sample Preparation in Proteomics.Analytical chemistry · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescent nanodiamonds (FNDs) are promising tools to image cells, bioanalytes and physical quantities such as temperature, pressure, and electric or magnetic fields with nanometer resolution. To exploit their potential for intracellular applications, the FNDs have to be brought into contact with cell culture media. The interactions between the medium and the diamonds crucially influence sensitivity as well as the ability to enter cells. The authors demonstrate that certain proteins and salts spontaneously adhere to the FNDs and may cause aggregation. This is a first investigation on the fundamental questions on how (a) FNDs interact with the medium, and (b) which proteins and salts are being attracted. A differentiation between strongly binding and weakly binding proteins is made. Not all proteins participate in the formation of FND aggregates. Surprisingly, some main components in the medium seem to play no role in aggregation. Simple strategies to prevent aggregation are discussed. These include adding the proteins, which are naturally present in the cell culture to the diamonds first and then inserting them in the full medium. Graphical abstractSchematic of the interaction of nanodiamonds with cell culture medium. Certain proteins and salts adhere to the diamond surface and lead to aggregation or to formation of a protein corona.
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