ArticleInternational journal of obesity (2005)2017
Choroid plexus aquaporin 1 and intracranial pressure are increased in obese rats: towards an idiopathic intracranial hypertension model?
Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Idiopathic Intracranial Hypertension Animal Models and Venous Sinus Stenting: Status of Disease and Device-Focused Evidence.Brain sciences · 2025Review
- Current Understanding of the Pathophysiology of Idiopathic Intracranial Hypertension.Current neurology and neuroscience reports · 2025Review
- Metabolic Dysfunction in Idiopathic Intracranial Hypertension: Current Theories and Updates.Aging and disease · 2024Review
- Progress and recognition of idiopathic intracranial hypertension: A narrative review.CNS neuroscience & therapeutics · 2024Review
- Idiopathic intracranial hypertension in two twin sisters.BMJ case reports · 2024Article
- CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension.Fluids and barriers of the CNS · 2024Article
- Review
- Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production.Fluids and barriers of the CNS · 2023Article
- Familial non-obese idiopathic intracranial hypertension.American journal of ophthalmology case reports · 2022Article
- The impact of obesity-related raised intracranial pressure in rodents.Scientific reports · 2022Article
- Differences in the choroid plexus volume and microstructure are associated with body adiposity.Frontiers in endocrinology · 2022Article
- Understanding the link between obesity and headache- with focus on migraine and idiopathic intracranial hypertension.The journal of headache and pain · 2021Review
- Reviewing the Recent Developments in Idiopathic Intracranial Hypertension.Ophthalmology and therapy · 2020Review
- Guide to preclinical models used to study the pathophysiology of idiopathic intracranial hypertension.Eye (London, England) · 2020Review
- Long-term monitoring of intracranial pressure in freely-moving rats; impact of different physiological states.Fluids and barriers of the CNS · 2020Article
- Controlled Decompression Attenuates Brain Injury in a Novel Rabbit Model of Acute Intracranial Hypertension.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Preclinical update on regulation of intracranial pressure in relation to idiopathic intracranial hypertension.Fluids and barriers of the CNS · 2019Review
- Review
- Article
- Characterization of Retinal Ganglion Cell and Optic Nerve Phenotypes Caused by Sustained Intracranial Pressure Elevation in Mice.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesIdiopathic intracranial hypertension (IIH) is a condition of increased intracranial pressure (ICP) without identifiable cause. The majority of IIH patients are obese, which suggests a connection between ICP and obesity. The aim of the study was to compare ICP in lean and obese rats. We also aimed to clarify if any ICP difference could be attributed to changes in some well-known ICP modulators; retinol and arterial partial pressure of CO
methodsICP was measured in obese and lean Zucker rats over a period of 28 days. Arterial pCO
resultsObese rats had elevated ICP compared to lean controls on all recording days except day 0 (P<0.001). Serum retinol (P=0.35) and arterial pCO
conclusionObese Zucker rats display intracranial hypertension and increased AQP1 expression in CP compared to lean controls. The mechanisms behind these changes are still unknown, but appear to be unrelated to altered pCO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.