Evidence map›Paper›PMID 28344345›Full record

Trial reportInternational journal of obesity (2005)2017

Gastric bypass surgery with exercise alters plasma microRNAs that predict improvements in cardiometabolic risk.

Y O Nunez Lopez, P M Coen, B H Goodpaster, A A Seyhan

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 5 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Effect of exercise training before and after bariatric surgery: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
    Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Review
  11. Article
  12. Trials and Tribulations of MicroRNA Therapeutics.International journal of molecular sciences · 2024
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Y O Nunez LopezTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, USA.
P M CoenTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, USA.
B H GoodpasterTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, USA.
A A SeyhanTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, USA.
Sanford Burnham Prebys Medical Discovery Institute · USTranslational Research Institute for Metabolism and Diabetes · US

Funding

WITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJM01RR000056 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVINE, ARTHUR S · 1985 to 2006
$29.2M
SKELETAL MUSCLE FREE FATTY ACID UPTAKE AND OXIDATION IN OBESITYP30DK046204 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JAKICIC, JOHN M · 1992 to 2009
$7.9M
Physical Activity Following Surgery-Induced Weight LossR01DK078192 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GOODPASTER, BRET H · 2008 to 2012
$3.0M
NCRR NIH HHS M01 RR000056NIDDK NIH HHS P30 DK046204NIDDK NIH HHS R01 DK078192
6 · The paper itself

Abstract

BACKGROUND/

objectivesRoux-en-Y gastric bypass (RYGB) surgery improves insulin sensitivity (S SUBJECTS/

methodsNinety-four miRNAs implicated in metabolism were profiled in plasma samples from 22 severely obese subjects who were recruited 1-3 months after RYGB surgery and followed for 6 months of RYGB surgery-induced weight loss, with (exercise program (EX), N=11) or without (CON, N=11) an exercise training intervention. The subjects were selected, considering a priori sample size calculations, among the participants in the parent study. Mixed-effect modeling for repeated measures and partial correlation analysis was implemented in the R environment for statistical analysis.

resultsMirroring results in the parent trial, both groups experienced significant weight loss and improvements in cardiometabolic risk. In the CON group, weight loss significantly altered the pattern of circulating miR-7, miR-15a, miR-34a, miR-106a, miR-122 and miR-221. In the EX group, a distinct miRNA signature was altered: miR-15a, miR-34a, miR-122, miR-135b, miR-144, miR-149 and miR-206. Several miRNAs were significantly associated with improvements in acute insulin response, S

conclusionsThese findings present novel insights into the RYGB surgery-induced molecular changes and the effects of mild exercise to facilitate and/or maintain the benefits of a 'comprehensive' weight-loss intervention with concomitant improvements in cardiometabolic functions. Notably, we show a predictive value for miR-7, miR-15a, miR-106b and miR-135b.

Indexed as

Gastric BypassAdultCardiovascular DiseasesDiabetes Mellitus, Type 2Disease ProgressionExerciseFemaleGene Expression ProfilingHumansInsulin ResistanceMaleMicroRNAsMiddle AgedObesity, MorbidRisk FactorsWeight LossMicroRNAs

Identifiers

PMID28344345
PMCPMC5576445
OpenAlexW2598469579

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.