ArticleNanomaterials (Basel, Switzerland)2016
Characterization of Nanoparticle Dispersion in Red Blood Cell Suspension by the Lattice Boltzmann-Immersed Boundary Method.
Article in Nanomaterials (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Multiscale physics-basedFrontiers in drug delivery · 2024Review
- A mathematical model of fibrinogen-mediated erythrocyte-erythrocyte adhesion.Communications biology · 2023Article
- Application of machine learning in predicting blood flow and red cell distribution in capillary vessel networks.Journal of the Royal Society, Interface · 2022Article
- A numerical study on drug deliveryNanoscale · 2021Article
- Multiscale modeling of protein membrane interactions for nanoparticle targeting in drug delivery.Current opinion in structural biology · 2020Review
- Endothelial Cell Targeting by cRGD-Functionalized Polymeric Nanoparticles under Static and Flow Conditions.Nanomaterials (Basel, Switzerland) · 2020Article
- Multiscale modeling of hemolysis during microfiltration.Microfluidics and nanofluidics · 2020Article
- Label-free sorting of soft microparticles using a bioinspired synthetic cilia array.Biomicrofluidics · 2018Article
- A parallel fluid-solid coupling model usingJournal of computational science · 2018Article
- Modeling thermal inkjet and cell printing process using modified pseudopotential and thermal lattice Boltzmann methods.Physical review. E · 2018Article
- Numerical simulation of cell squeezing through a micropore by the immersed boundary method.Proceedings of the Institution of Mechanical Engineers. Part C. Journal of mechanical engineering science · 2018Article
- Modeling and Synthesis of Ag and Ag/Ni Allied Bimetallic Nanoparticles by Green Method: Optical and Biological Properties.International journal of biomaterials · 2018Article
- A Cellular Model of Shear-Induced Hemolysis.Artificial organs · 2017Article
- Nanoparticle transport and delivery in a heterogeneous pulmonary vasculature.Journal of biomechanics · 2017Article
- Predicting different adhesive regimens of circulating particles at blood capillary walls.Microfluidics and nanofluidics · 2017Article
- Nanomaterials for Biosensing Applications.Nanomaterials (Basel, Switzerland) · 2016Article
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5 authors.
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Abstract
Nanodrug-carrier delivery in the blood stream is strongly influenced by nanoparticle (NP) dispersion. This paper presents a numerical study on NP transport and dispersion in red blood cell (RBC) suspensions under shear and channel flow conditions, utilizing an immersed boundary fluid-structure interaction model with a lattice Boltzmann fluid solver, an elastic cell membrane model and a particle motion model driven by both hydrodynamic loading and Brownian dynamics. The model can capture the multiphase features of the blood flow. Simulations were performed to obtain an empirical formula to predict NP dispersion rate for a range of shear rates and cell concentrations. NP dispersion rate predictions from the formula were then compared to observations from previous experimental and numerical studies. The proposed formula is shown to accurately predict the NP dispersion rate. The simulation results also confirm previous findings that the NP dispersion rate is strongly influenced by local disturbances in the flow due to RBC motion and deformation. The proposed formula provides an efficient method for estimating the NP dispersion rate in modeling NP transport in large-scale vascular networks without explicit RBC and NP models.
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