ArticleJournal of atherosclerosis and thrombosis2017
Significance of Serum Polyunsaturated Fatty Acid Level Imbalance in Patients with Acute Venous Thromboembolism.
Article in Journal of atherosclerosis and thrombosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Role of thromboelastography in risk stratifying patients with traumatic brain injury on prehospital antiplatelet agents.Trauma surgery & acute care open · 2026Article
- High concentrations of polyunsaturated n-3 fatty acids in serum are inversely associated with risk of future incident venous thromboembolism - the HUNT cohort study.The American journal of clinical nutrition · 2025Article
- Two-sample Mendelian randomization analysis reveals causal relationships between blood lipids and venous thromboembolism.Haematologica · 2024Article
- Potential causal relationships between blood metabolites, inflammatory cytokines, and venous thromboembolism.Frontiers in immunology · 2024Article
- Lipidomic Characterization and Antioxidant Activity of Macro- and Microalgae Blend.Life (Basel, Switzerland) · 2023Article
- Optimal Dose of n-3 Polyunsaturated Fatty Acids for Cardiovascular Event Prevention.Circulation reports · 2020Article
- The Current Conditions and Lifestyles of Obese University Students.Journal of clinical medicine research · 2018Article
- Association of a Low Serum Eicosapentaenoic Acid/Arachidonic Acid Ratio with the Risk of Acute Venous Thromboembolism.Journal of atherosclerosis and thrombosis · 2017Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimPolyunsaturated fatty acids (PUFAs) take part in various biological events linked to the pathogenesis of venous thromboembolism (VTE), including inflammation, endothelial dysfunction, and hypercoagulability. Several studies have demonstrated the association between PUFAs and the occurrence of VTE. However, the role of PUFAs in the pathogenesis of VTE remains unclear.
methodsWe enrolled 45 patients with acute VTE and 37 age-, gender-, and body mass index-matched healthy volunteers to examine their PUFA levels. Serum omega 3 (eicosapentaenoic acid: EPA and docosahexaenoic acid: DHA) and omega 6 (dihomogammalinolenic acid: DGLA and arachidonic acid: AA) fatty acids levels were measured within 24 h of admission.
resultsPatients with VTE showed significantly higher AA and lower EPA levels, and lower EPA/AA ratios than the controls. Multivariate analysis revealed that AA was an independent marker for VTE. In addition, we divided the patients based on their median age (58 years old). The younger patients with VTE showed significantly lower EPA/AA levels than their age-matched controls, whereas older patients with VTE showed a significantly higher AA/DGLA levels than the older controls.
conclusionsHigh serum AA levels and low EPA levels are associated with the development of acute VTE, suggesting that the imbalance of PUFAs may be a potential therapeutic target for preventing acute VTE.
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