ArticleBiochimica et biophysica acta. Molecular basis of disease2017
High-sucrose-induced maternal obesity disrupts ovarian function and decreases fertility in Drosophila melanogaster.
Article in Biochimica et biophysica acta. Molecular basis of disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Gestational exposure to the artificial sweetener erythritol reprograms ovarian function through AMH suppression and oxidative stress-mediated disruption of autophagy and PI3K signaling.Frontiers in endocrinology · 2026Article
- High-Fat and High-Sugar Diet Induces Murine Premature Ovarian Failure by Promoting Mitochondrial Oxidative Phosphorylation Response.Food science & nutrition · 2025Article
- Comparative Transcriptome Analysis of the Effects of a Non-Insect Artificial Diet on the Nutritional Development ofInsects · 2025Article
- Diet-induced plasticity of life-history traits and gene expression in outbredEcology and evolution · 2024Article
- A high-sugar diet, but not obesity, reduces female fertility in Drosophila melanogaster.Development (Cambridge, England) · 2023Article
- High-Sucrose Diet Exposure on Larvae Contributes to Adult Fecundity and Insecticide Tolerance in the Oriental Fruit Fly,Insects · 2023Article
- MiR-2b-2-5p regulates lipid metabolism and reproduction by targetingRNA biology · 2023Article
- Methods to Analyze Nutritional and Inter-Organ Control of Drosophila Ovarian Germline Stem Cells.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Modeling Obesity-Associated Ovarian Dysfunction inNutrients · 2022Article
- Phenotyping ofBiomolecules · 2022Review
- Female infertility and diet, is there a role for a personalized nutritional approach in assisted reproductive technologies? A Narrative Review.Frontiers in nutrition · 2022Review
- Sexual Dimorphism in Metabolic Responses to Western Diet inBiomolecules · 2021Article
- Short-term maintenance on a high-sucrose diet alleviates aging-induced sleep fragmentation inAnimal cells and systems · 2021Article
- Prepregnant Obesity of Mothers in a Multiethnic Cohort Is Associated with Cord Blood Metabolomic Changes in Offspring.Journal of proteome research · 2020Article
- Effects of obesity and weight loss on mitochondrial structure and function and implications for colorectal cancer risk.The Proceedings of the Nutrition Society · 2019Article
- Mitochondrial inefficiency in infants born to overweight African-American mothers.International journal of obesity (2005) · 2018Observational
- Obesity and Aging in theInternational journal of molecular sciences · 2018Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
As the obesity epidemic worsens, the prevalence of maternal obesity is expected to rise. Both high-fat and high-sucrose diets are known to promote maternal obesity and several studies have elucidated the molecular influence of high-fat feeding on female reproduction. However, to date, the molecular impact of a high-sucrose diet on maternal obesity remains to be investigated. Using our previously reported Drosophila high-sucrose maternal obesity model, we sought to determine how excess dietary sucrose impacted the ovary. High-sucrose diet (HSD) fed adult females developed systemic insulin resistance and exhibited an ovarian phenotype characterized by excess accumulation of lipids and cholesterol in the ovary, decreased ovary size, and impaired egg maturation. We also observed decreased expression of antioxidant genes and increased protein carbonylation in the ovaries of HSD females. HSD females laid fewer eggs; however, the overall survival of offspring was unchanged relative to lean control females. Ovaries of HSD females had increased mitochondrial DNA copy number and decreased expression of key mitochondrial regulators, suggestive of an ineffective compensatory response to mitochondrial dysfunction. Mitochondrial alterations were also observed in male offspring of obese females. This study demonstrates that high-sucrose-induced maternal obesity promotes insulin resistance, while disrupting ovarian metabolism and function.
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