Evidence map›Paper›PMID 28344124›Full record

ArticleMicrobial pathogenesis2017

Comparative genomics of transport proteins in probiotic and pathogenic Escherichia coli and Salmonella enterica strains.

Jimmy Do, Hassan Zafar, Milton H Saier

Abstract read
In one paragraph

Article in Microbial pathogenesis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Role of adherent invasiveWorld journal of clinical cases · 2022
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Epi-Gene: An R-Package for Easy Pan-Genome Analysis.BioMed research international · 2021
    Article
  13. Review
  14. Article
  15. Transporters of glucose and other carbohydrates in bacteria.Pflugers Archiv : European journal of physiology · 2020
    Review
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jimmy DoDepartment of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0116, USA.
Hassan ZafarDepartment of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0116, USA.
Milton H SaierDepartment of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0116, USA. Electronic address: msaier@ucsd.edu.
University of California, San Diego · US

Funding

The Transporter Classification Database (TCDB)R01GM077402 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAIER, MILTON H. · 2006 to 2021
$4.7M
Integrative functional mapping of the Escherichia coli membrane interactomeR01GM109895 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI SAIER, MILTON H., UETZ, PETER HANS · 2014 to 2017
$1.1M
NIGMS NIH HHS R01 GM077402NIGMS NIH HHS R01 GM109895
6 · The paper itself

Abstract

Escherichia coli is a genetically diverse species that can be pathogenic, probiotic, commensal, or a harmless laboratory strain. Pathogenic strains of E. coli cause urinary tract infections, diarrhea, hemorrhagic colitis, and pyelonephritis, while the two known probiotic E. coli strains combat inflammatory bowel disease and play a role in immunomodulation. Salmonella enterica, a close relative of E. coli, includes two important pathogenic serovars, Typhi and Typhimurium, causing typhoid fever and enterocolitis in humans, respectively, with the latter strain also causing a lethal typhoid fever-like disease in mice. In this study, we identify the transport systems and their substrates within seven E. coli strains: two probiotic strains, two extracellular pathogens, two intracellular pathogens, and K-12, as well as the two intracellular pathogenic S. enterica strains noted above. Transport systems characteristic of each probiotic or pathogenic species were thus identified, and the tabulated results obtained with all of these strains were compared. We found that the probiotic and pathogenic strains generally contain more iron-siderophore and sugar transporters than E. coli K-12. Pathogens have increased numbers of pore-forming toxins, protein secretion systems, decarboxylation-driven Na

Indexed as

GenomicsBacterial Outer Membrane ProteinsBacterial ProteinsCarrier ProteinsEscherichia coliEscherichia coli InfectionsGenome, BacterialProbioticsSalmonella entericaSalmonella InfectionsSalmonella typhiSalmonella typhimuriumSiderophoresVirulence FactorsBacterial Outer Membrane ProteinsBacterial ProteinsCarrier ProteinsSiderophoresVirulence FactorsE. coliPathogensPhysiologyProbioticsSalmonella entericaTransport proteins

Identifiers

PMID28344124
PMCPMC5591646
OpenAlexW2598667758

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.