ArticleNeuron2017
Grid and Nongrid Cells in Medial Entorhinal Cortex Represent Spatial Location and Environmental Features with Complementary Coding Schemes.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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Who cites it
112 citing papers in PubMed.
- Spatial and temporal representations are organized along a stable coding gradient in the medial entorhinal cortex.bioRxiv : the preprint server for biology · 2026Article
- Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice.Cell reports · 2026Article
- Grid maps are disrupted after large-scale arena expansion and recover with experience.Nature communications · 2026Article
- The entorhinal spatial map integrates visual identity information of landmarks.Nature communications · 2026Article
- The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations.Nature neuroscience · 2026Article
- Entorhinal cortex represents task-relevant remote locations independently of CA1.Nature neuroscience · 2026Article
- Non-Canonical Subiculum Circuit Organization and Function.Hippocampus · 2026Review
- Temporal Coding rather than Circuit Wiring allows Hippocampal CA3 Neurons to Dynamically Distinguish Different Cortical Inputs.bioRxiv : the preprint server for biology · 2026Article
- Reproducible and predictable reorganization of place fields driven by grid subfield rate changes.bioRxiv : the preprint server for biology · 2026Article
- REMI: Reconstructing Episodic Memory During Internally Driven Path Planning.bioRxiv : the preprint server for biology · 2025Article
- Spatial coding dysfunction and network instability in the aging medial entorhinal cortex.Nature communications · 2025Article
- Cortical dissociation of spatial reference frames during place navigation.bioRxiv : the preprint server for biology · 2025Article
- Object-translocation induces event coding in the rat hippocampus.Communications biology · 2025Article
- Article
- Translational differentiation of vertically displaced surfaces by grid cells.Current biology : CB · 2025Article
- Hippocampus shapes entorhinal cortical output through a direct feedback circuit.Nature neuroscience · 2025Article
- The Inner Ear and Aging Brain: A Cross-Sectional Study of Vestibular Function and Morphometric Variations in the Entorhinal and Trans-Entorhinal Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- A unified neural representation model for spatial and conceptual computations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Robust variability of grid cell properties within individual grid modules enhances encoding of local space.eLife · 2025Article
- The role of oscillations in grid cells' toroidal topology.PLoS computational biology · 2025Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The medial entorhinal cortex (mEC) has been identified as a hub for spatial information processing by the discovery of grid, border, and head-direction cells. Here we find that in addition to these well-characterized classes, nearly all of the remaining two-thirds of mEC cells can be categorized as spatially selective. We refer to these cells as nongrid spatial cells and confirmed that their spatial firing patterns were unrelated to running speed and highly reproducible within the same environment. However, in response to manipulations of environmental features, such as box shape or box color, nongrid spatial cells completely reorganized their spatial firing patterns. At the same time, grid cells retained their spatial alignment and predominantly responded with redistributed firing rates across their grid fields. Thus, mEC contains a joint representation of both spatial and environmental feature content, with specialized cell types showing different types of integrated coding of multimodal information.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.