ReviewMovement disorders : official journal of the Movement Disorder Society2017
Motor learning in animal models of Parkinson's disease: Aberrant synaptic plasticity in the motor cortex.
Review in Movement disorders : official journal of the Movement Disorder Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Comparative efficacy of transcranial magnetic stimulation on different targets in Parkinson's disease: A Bayesian network meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Driving motor cortex oscillations restores plasticity and improves bradykinesia features in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Cardiovascular exercise enhances motor learning across multiple sessions in people with Parkinson's disease: a randomized controlled pilot trial.NPJ science of learning · 2025Article
- Effects of Agility Training with a Light-Based System on Balance and Functional Performance in Individuals with Parkinson's Disease.Healthcare (Basel, Switzerland) · 2025Article
- Preclinical and clinical study on type 3 metabotropic glutamate receptors in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Neurophysiological markers of motor compensatory mechanisms in early Parkinson's disease.Brain : a journal of neurology · 2024Article
- Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons.Neuron · 2022Article
- Striatal synaptic adaptations in Parkinson's disease.Neurobiology of disease · 2022Review
- Comparative Ultrastructural Analysis of Thalamocortical Innervation of the Primary Motor Cortex and Supplementary Motor Area in Control and MPTP-Treated Parkinsonian Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Roles of Motor Cortex Neuron Classes in Reach-Related Modulation for Hemiparkinsonian Rats.Frontiers in neuroscience · 2021Article
- Neurotransmitters, Cell Types, and Circuit Mechanisms of Motor Skill Learning and Clinical Applications.Frontiers in neurology · 2021Review
- Novel functional variants at the GWAS-implicated loci might confer risk to major depressive disorder, bipolar affective disorder and schizophrenia.BMC neuroscience · 2018Article
- The protective effects of crocin in the management of neurodegenerative diseases: a review.American journal of neurodegenerative disease · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
In Parkinson's disease (PD), dopamine depletion causes major changes in the brain, resulting in the typical cardinal motor features of the disease. PD neuropathology has been restricted to postmortem examinations, which are limited to only a single time of PD progression. Models of PD in which dopamine tone in the brain is chemically or physically disrupted are valuable tools in understanding the mechanisms of the disease. The basal ganglia have been well studied in the context of PD, and circuit changes in response to dopamine loss have been linked to the motor dysfunctions in PD. However, the etiology of the cognitive dysfunctions that are comorbid in PD patients has remained unclear until now. In this article, we review recent studies exploring how dopamine depletion affects the motor cortex at the synaptic level. In particular, we highlight our recent findings on abnormal spine dynamics in the motor cortex of PD mouse models through in vivo time-lapse imaging and motor skill behavior assays. In combination with previous studies, a role of the motor cortex in skill learning and the impairment of this ability with the loss of dopamine are becoming more apparent. Taken together, we conclude with a discussion on the potential role for the motor cortex in PD, with the possibility of targeting the motor cortex for future PD therapeutics. © 2017 International Parkinson and Movement Disorder Society.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.