ArticleJournal of endocrinological investigation2017
Prevalence of thyroid dysfunction and its impact on cognition in older mexican adults: (SADEM study).
Article in Journal of endocrinological investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Association of overt hypothyroidism with risks of cognitive impairment: a meta-analysis and systematic review.Frontiers in endocrinology · 2025Pooled it
- Thyroid Dysfunction and Cognitive Impairment: Neural Mechanisms and Neurofeedback-Based Interventions.Brain and behavior · 2026Review
- The impact of autoimmune thyroid disease on cognitive and psychiatric disorders: focus on clinical, pre-clinical and molecular studies.European thyroid journal · 2025Review
- Thyroid function status and heterogeneity of efficacy of maintenance cognitive stimulation in late-life dementia: a stratified observational study of subclinical hypothyroidism/hyperthyroidism.Frontiers in neurology · 2025Article
- Thyroid Function and Cognitive Decline: A Narrative Review.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2024Review
- [Occult thyroid dysfunction in outpatients with liver cirrhosis].Revista medica del Instituto Mexicano del Seguro Social · 2024Article
- Evaluation of the risk of hypothyroidism and its clinical manifestations using the Zulewski scale.Frontiers in endocrinology · 2024Article
- Prevalence of thyroid dysfunction among Iranian older adults: a cross-sectional study.Scientific reports · 2023Article
- Subclinical Hypothyroidism is Associated with Cognitive Impairment in Patients with Cerebral Small Vessel Disease.Neuropsychiatric disease and treatment · 2023Article
- Association of Hypothyroidism and the Risk of Cognitive Dysfunction: A Meta-Analysis.Journal of clinical medicine · 2022Review
- TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor.Cell chemical biology · 2022Article
- Depressive Symptoms and Cognitive Decline Among Chinese Rural Elderly Individuals: A Longitudinal Study With 2-Year Follow-Up.Frontiers in public health · 2022Article
- The Association Between Thyroid Diseases and Alzheimer's Disease in a National Health Screening Cohort in Korea.Frontiers in endocrinology · 2022Article
- The relation between thyroid dysregulation and impaired cognition/behaviour: An integrative review.Journal of neuroendocrinology · 2021Review
- Prevalence and Risk Factors of Thyroid Dysfunction in Older Adults in the Community.Scientific reports · 2019Article
- Relevance of TSH evaluation in elderly in-patients with non-thyroidal illness.Journal of endocrinological investigation · 2019Article
- Thyroid disorders in Brazil: the contribution of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Article
- Mouse Thyroid Gland Changes in Aging: Implication of Galectin-3 and Sphingomyelinase.Mediators of inflammation · 2017Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
introductionSubclinical thyroid dysfunction is a possible risk factor for cognitive impairment in old age, but results are inconsistent. Aim of the present study was to evaluate the prevalence of thyroid dysfunction among older community-dwelling adults and to see whether thyroid function impacts the cognitive status of the elderly.
methodsWe included 1750 participants from the Study on Aging and Dementia in Mexico (SADEM). All subjects were evaluated clinically via specific interviews. TSH levels were analyzed by chemiluminescent immunometry assay. We classified participants into five thyroid state groups: (1) normal TSH levels (0.40-4.0 IU/L) were considered euthyroid; (2) Overt hyperthyroidism: TSH <0.3 IU/l and FT4 >23 pmol/l; (3) Overt hypothyroidism: TSH >4.8 IU/l, FT4 <13 pmol/l; (4) Subclinical hyperthyroidism: TSH <0.3 IU/l, FT4: 13-23 pmol/l; (5) Subclinical hypothyroidism: TSH >4.8 IU/l, FT4: 13-23 pmol/l.
resultsThe overall estimated prevalence of thyroid dysfunction in Mexican population was 23.7% (95% CI, 22.66-26.77). Of these, 15.4% older adults were classified as subclinical hypothyroidism, 7.2% overt hypothyroidism, 0.5% subclinical hyperthyroidism, and 0.6% overt hyperthyroidism. The association of thyroid dysfunction with cognitive impairment was most evident in overt hypothyroidism OR = 1.261 (1.185-1.343).
conclusionsThe present study demonstrated a high prevalence of thyroid dysfunction in Mexican elderly people living in the community. A relationship between cognitive impairment and the presence of hypothyroidism was also shown, and to a lesser degree in hyperthyroidism.
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