ArticleMolecular and cellular biochemistry2017
Steroidogenic genes expressions are repressed by high levels of leptin and the JAK/STAT signaling pathway in MA-10 Leydig cells.
Article in Molecular and cellular biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Obesity and Sex Affect the Immune Responses to Tick-Borne Encephalitis Booster Vaccination.Frontiers in immunology · 2020Trial
- Leptin Acts as a Peripheral Tropic Signal to Tune Steroidogenesis.bioRxiv : the preprint server for biology · 2026Article
- The mediating role of testosterone in the relationship between body fat percentage and diabetes mellitus risk.Frontiers in endocrinology · 2026Article
- Testosterone and Obesity in an Aging Society.Biomolecules · 2025Review
- Immune Microenvironment Dysregulation: A Contributing Factor to Obesity-Associated Male Infertility.Biomedicines · 2025Review
- Obesity, White Adipose Tissue, and Adipokines Signaling in Male Reproduction.Molecular nutrition & food research · 2025Review
- The role of leptin in the male reproductive system.Journal of the Turkish German Gynecological Association · 2024Article
- Signatures of metabolic diseases on spermatogenesis and testicular metabolism.Nature reviews. Urology · 2024Review
- Review
- Elevated serum leptin may be associated with disease activity and secondary osteoporosis in Chinese patients with rheumatoid arthritis.Clinical rheumatology · 2023Article
- Involvement of calmodulin-dependent protein kinase I in the regulation of the expression of connexin 43 in MA-10 tumor Leydig cells.Molecular and cellular biochemistry · 2023Article
- The Hypothalamic-Pituitary-Gonadal Axis in Men with Schizophrenia.International journal of molecular sciences · 2023Review
- Basic Leucine Zipper Transcription Factors as Important Regulators of Leydig Cells' Functions.International journal of molecular sciences · 2022Review
- Adipose Tissue Dysfunction and Obesity-Related Male Hypogonadism.International journal of molecular sciences · 2022Review
- The Head-to-Toe Hormone: Leptin as an Extensive Modulator of Physiologic Systems.International journal of molecular sciences · 2022Review
- The AP-1 family of transcription factors are important regulators of gene expression within Leydig cells.Endocrine · 2021Review
- Functional Analysis of Steroidogenic Factor 1 (sf-1) and 17α-Hydroxylase/Lyase (cyp17α) Promoters in Yellow CatfishInternational journal of molecular sciences · 2020Article
- Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism.Antioxidants (Basel, Switzerland) · 2020Review
- Association of Leptin with Total and Free Testosterone: Results from the National Health and Nutrition Examination Surveys.Androgens: clinical research and therapeutics · 2020Article
- The intake of an extract from seeds ofHeliyon · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
The adipose tissue is an important endocrine organ secreting numerous peptide hormones, including leptin. Increased circulating levels of leptin, as a result of hormonal resistance in obese individuals, may contribute to lower androgen production in obese males. However, the molecular mechanisms involved need to be better defined. Androgens are mainly produced by Leydig cells within the testis. In male rodents, activation of the leptin receptor modulates a cascade of intracellular signal transduction pathways which may lead to regulation of transcription factors having influences on steroidogenesis in Leydig cells. Thus, as a result of high leptin levels interacting with its receptor and modulating the activity of the JAK/STAT signaling pathway, the activity of transcription factors important for steroidogenic genes expressions may be inhibited in Leydig cells. Here we show that Lepr is increasingly expressed within Leydig cells according to postnatal development. Although high levels of leptin (corresponding to obesity condition) alone had no effect on Leydig cells' steroidogenic genes expression, it downregulated cAMP-dependent activations of the cholesterol transporter Star and of the rate-limiting steroidogenic enzyme Cyp11a1. Our results suggest that STAT transcriptional activity is downregulated by high levels of leptin, leading to reduced cAMP-dependent steroidogenic genes (Star and Cyp11a1) expressions in MA-10 Leydig cells. However, other transcription factors such as members of the SMAD and NFAT families may be involved and need further investigation to better define how leptin regulates their activities and their relevance for Leydig cells function.
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