Evidence map›Paper›PMID 28343066›Full record

ArticleBiophysical chemistry2017

Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel Na

Liam Hovey, C Andrew Fowler, Ryan Mahling, Zesen Lin, Mark Stephen Miller, Dagan C Marx, Jesse B Yoder, Elaine H Kim, Kristin M Tefft, Brett C Waite and 3 more

Open access · greenAbstract read
In one paragraph

Article in Biophysical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. NaStructure (London, England : 1993) · 2021
    Article
  3. Do calmodulin binding IQ motifs have built-in capping domains?Protein science : a publication of the Protein Society · 2021
    Review
  4. Properties of Calmodulin Binding to NaNeurochemical research · 2021
    Article
  5. Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation.The Journal of general physiology · 2021
    Review
  6. [Effect of calmodulin and its mutants on binding to NaZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2020
    Article
  7. Article
  8. Review
  9. Crystal structures of CaProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  10. The Crossroad of Ion Channels and Calmodulin in Disease.International journal of molecular sciences · 2019
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. CaThe Journal of biological chemistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Liam HoveyDepartment of Biochemistry, University of Iowa, 52242-1109 Iowa City, United States.
C Andrew FowlerNMR Facility, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 52242-1109 Iowa City, United States.
Ryan MahlingDepartment of Biochemistry, University of Iowa, 52242-1109 Iowa City, United States.
Zesen LinDepartment of Biochemistry, University of Iowa, 52242-1109 Iowa City, United States.
Mark Stephen MillerDepartment of Biochemistry, University of Iowa, 52242-1109 Iowa City, United States.
Dagan C MarxDepartment of Biochemistry, University of Iowa, 52242-1109 Iowa City, United States.
Jesse B YoderDepartment of Biochemistry, University of Iowa, 52242-1109 Iowa City, United States.
Elaine H KimDepartment of Biochemistry, University of Iowa, 52242-1109 Iowa City, United States.
Kristin M TefftDepartment of Biochemistry, University of Iowa, 52242-1109 Iowa City, United States.
Brett C WaiteDepartment of Biochemistry, University of Iowa, 52242-1109 Iowa City, United States.
Michael D FeldkampDepartment of Biochemistry, University of Iowa, 52242-1109 Iowa City, United States.
Liping YuNMR Facility, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 52242-1109 Iowa City, United States.
Madeline A SheaDepartment of Biochemistry, University of Iowa, 52242-1109 Iowa City, United States. Electronic address: madeline-shea@uiowa.edu.
University of Iowa · US

Funding

PROGRAM IN MOLECULAR BIOPHYSICST32GM008403 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BARRICK, DOUGLAS E. · 1990 to 2019
$13.5M
PREDOCTORAL TRAINING PROGRAM IN BIOTECHNOLOGYT32GM008365 · NIGMS · UNIVERSITY OF IOWA · PI KERNS, ROBERT JOHN · 1990 to 2021
$3.8M
MOLECULAR DISSECTION OF CALMODULIN DOMAIN INTERACTIONSR01GM057001 · NIGMS · UNIVERSITY OF IOWA · PI SHEA, MADELINE A · 1998 to 2015
$2.9M
NIGMS NIH HHS R01 GM057001NIGMS NIH HHS T32 GM008365NIGMS NIH HHS T32 GM008403
6 · The paper itself

Abstract

Several members of the voltage-gated sodium channel family are regulated by calmodulin (CaM) and ionic calcium. The neuronal voltage-gated sodium channel Na

Indexed as

Amino Acid MotifsAnimalsBinding SitesCalciumCalmodulinNAV1.2 Voltage-Gated Sodium ChannelNerve Tissue ProteinsNuclear Magnetic Resonance, BiomolecularRatsCalciumCalmodulinNAV1.2 Voltage-Gated Sodium ChannelNerve Tissue ProteinsAllosteryBindingBiosensorFree energyFRETLinkageMolecular recognitionNMRSodium channelsThermodynamicsTitration

Identifiers

PMID28343066
PMCPMC5503752
OpenAlexW2593761439

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.