Evidence map›Paper›PMID 28343035›Full record

ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2017

Evaluation of 4-methylcyclohexanemethanol (MCHM) in a combined irritancy and Local Lymph Node Assay (LLNA) in mice.

Victor J Johnson, Scott S Auerbach, Michael I Luster, Suramya Waidyanatha, Scott A Masten, Mary S Wolfe, Florence G Burleson, Gary R Burleson, Dori R Germolec

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Victor J JohnsonBurleson Research Technologies, Inc., Morrisville, NC, USA. Electronic address: vjohnson@brt-labs.com.
Scott S AuerbachNational Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Michael I LusterBurleson Research Technologies, Inc., Morrisville, NC, USA.
Suramya WaidyanathaNational Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Scott A MastenNational Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Mary S WolfeNational Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Florence G BurlesonBurleson Research Technologies, Inc., Morrisville, NC, USA.
Gary R BurlesonBurleson Research Technologies, Inc., Morrisville, NC, USA.
Dori R GermolecNational Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
National Institute of Environmental Health Sciences · USInfineon Technologies (United States) · US

Funding

Toxicological Assessments for the National Toxicology ProgramZIAES103316 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, NIGEL J · 2016 to 2019
$31.9M
Intramural NIH HHS Z99 ES999999NIEHS NIH HHS HHSN273201400017C
6 · The paper itself

Abstract

4-Methylcyclohexanemethanol (MCHM) is a flotation reagent used in fine coal beneficiation. On January 9, 2014, crude MCHM, a mixture containing predominantly MCHM, was inadvertently released into the Elk River, a municipal water source that serves about 300,000 people in the Charleston, WV area, resulting in temporary contamination of 15 percent of the state's tap water and causing significant dermal exposure. The current studies were undertaken to determine whether crude MCHM or MCHM has the potential to produce dermal irritancy and/or sensitization. BALB/c female mice were treated daily for 3 consecutive days by direct epicutaneous application of 25 μL of various concentrations of crude MCHM or MCHM to the dorsum of each ear. A mouse ear-swelling test was used to determine irritancy potential and was undertaken in combination with the standardized Local Lymph Node Assay (LLNA) to determine skin sensitizing potential. MCHM was found to produce skin irritation at concentrations above 20% and did not produce sensitization. Crude MCHM also produced irritation, although weaker, and in addition was found to be a weak to moderate skin sensitizer. The results are discussed in terms of potential human health hazard.

Indexed as

AnimalsCyclohexanesDermatitis, Allergic ContactFemaleHumansIrritantsLocal Lymph Node AssayMiceMice, Inbred BALB CSkin Irritancy TestsWater Pollutants, Chemical4-methylcyclohexanemethanolCyclohexanesIrritantsWater Pollutants, Chemical4-MethylcyclohexanemethanolAllergic contactDermal hypersensitivityDermal irritancyDermatitis (ACD)Elk River spillLocal Lymph Node Assay (LLNA)

Identifiers

PMID28343035
PMCPMC5594409
OpenAlexW2600504357

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.