Evidence map›Paper›PMID 28342988›Full record

Trial reportContemporary clinical trials2017

An anti-inflammatory dietary intervention to reduce breast cancer recurrence risk: Study design and baseline data.

Amelie G Ramirez, Dorothy Long Parma, Edgar Muñoz, Kristin D Mendoza, Crystel Harb, Alan E C Holden, Michael Wargovich

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Contemporary clinical trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03987776 (The Effect of an Anti-Inflammatory Diet on Weight Loss, Body Composition, Cardiometabolic Risk Factors and Immune System Response in Younger Adults), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03987776 nacompletednot on this mapstarted 2019, after this paper: background citation

The Effect of an Anti-Inflammatory Diet on Weight Loss, Body Composition, Cardiometabolic Risk Factors and Immune System Response in Younger Adults

TypeinterventionalSponsorClinical Hospital Center RijekaRan2019 to 2023Enrolled220ConditionsObesityArmsAnti-inflammatory energy-restricted diet, Control energy-restricted diet
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Body weight management in overweight and obese breast cancer survivors.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. Effect of an anti-inflammatory dietary intervention on quality of life among breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Amelie G RamirezDepartment of Epidemiology and Biostatistics, The University of Texas Health Science Center at San Antonio, USA. Electronic address: ramirezag@uthscsa.edu.
Dorothy Long ParmaDepartment of Epidemiology and Biostatistics, The University of Texas Health Science Center at San Antonio, USA.
Edgar MuñozDepartment of Epidemiology and Biostatistics, The University of Texas Health Science Center at San Antonio, USA.
Kristin D MendozaDepartment of Epidemiology and Biostatistics, The University of Texas Health Science Center at San Antonio, USA.
Crystel HarbDepartment of Epidemiology and Biostatistics, The University of Texas Health Science Center at San Antonio, USA.
Alan E C HoldenDepartment of Epidemiology and Biostatistics, The University of Texas Health Science Center at San Antonio, USA.
Michael WargovichDepartment of Molecular Medicine, The University of Texas Health Science Center at San Antonio, USA.
The University of Texas Health Science Center at San Antonio · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
THE FEASIBILITY STUDIES FOR COLLABORATIVE INTERACTION FOR MINORITY INSTITUTE/CANP20CA165589 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LEACH, ROBIN JEAN · 2012 to 2015
$777k
The Cancer Bioinformatics Initiative: A UTSA/UTHSCSA Partnership (2 of 2)P20CA165583 · NCI · UNIVERSITY OF TEXAS SAN ANTONIO · PI ROBBINS, KAY A · 2012 to 2015
$552k
NCI NIH HHS P20 CA165583NCI NIH HHS P20 CA165589NCI NIH HHS P30 CA054174
6 · The paper itself

Abstract

U.S. breast cancer survivors (BCSs) are expected to increase to 4 million in the next 5-10years. Cancer recurrence risk is highest among obese survivors. Inflammatory (Pro-I) biomarkers including C-reactive protein (CRP), Interleukins -3, -6, and -8 (IL-3, IL-6, IL-8), and Tumor Necrosis Factor (TNF)-α have been associated with cancer recurrence risk. Nutritional interventions aimed at reducing inflammation (INF) may contribute to reduced cancer recurrence risk, but studies have been limited to animal models. The goals of this one-year, culinary-based, pilot intervention were to: 1) decrease Pro-I biomarkers and increase anti-inflammatory (AI) cytokine, IL-10, by promoting AI food incorporation into BCS diets; and 2) examine intervention effects on cancer risk factors including body mass index (BMI) and circulating adipose stromal cells (ASCs). A total of 153 BCSs were recruited. Overweight and obese women aged 18 or older were randomized into Intervention (IG; n=76) and Control (CG; n=77) groups. CG received monthly nutritional brochures from the American Institute for Cancer Research. IG attended 6 monthly workshops (lectures on AI topics and chef-prepared food demonstrations), and received monthly newsletters and telephone calls incorporating Motivational Interviewing. At baseline, 6- and 12-month assessments, fasting serum was assayed for Pro-I/AI marker and ASC levels. Using R and Stata version 14 (Stata Corp, 2015), no significant differences were found between groups on baseline demographic variables. Correlations between serum cytokine levels, BMI, % body fat, ASCs, and self-reported variables are discussed.

Indexed as

Adipose TissueBiomarkersBody Mass IndexBreast NeoplasmsCell CountC-Reactive ProteinFemaleHumansInterleukin-10InterleukinsMiddle AgedMotivational InterviewingNeoplasm Recurrence, LocalSecondary PreventionStromal CellsTumor Necrosis Factor-alphaBiomarkersC-Reactive ProteinInterleukin-10InterleukinsTumor Necrosis Factor-alphaBiomarkerBreast cancer survivorsInflammationObesity

Identifiers

PMID28342988
PMCPMC6110085
OpenAlexW2598978669

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.