Evidence map›Paper›PMID 28342916›Full record

ArticleThe Journal of allergy and clinical immunology2017

Granulocyte transfusions in patients with chronic granulomatous disease and refractory infections: The NIH experience.

Beatriz E Marciano, Elisabeth S Allen, Cathy Conry-Cantilena, Ervand Kristosturyan, Harvey G Klein, Thomas A Fleisher, Steven M Holland, Harry L Malech, Sergio D Rosenzweig

Registry-linked trialOpen access · greenAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05189925 (NADPH Oxidase Correction in mRNA Transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05189925 phase1recruitingnot on this mapstarted 2022, after this paper: background citation

NADPH Oxidase Correction in mRNA Transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD)

TypeinterventionalSponsorNational Institute of Allergy and Infectious Diseases (NIAID)Ran2022 to 2027Enrolled25ConditionsChronic Granulomatous Disease, InfectionArmsgp91 Grans
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Chronic Granulomatous Disease: a Comprehensive Review.Clinical reviews in allergy & immunology · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Advances and highlights in primary immunodeficiencies in 2017.The Journal of allergy and clinical immunology · 2018
    Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Beatriz E MarcianoLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, Md.
Elisabeth S AllenDepartment of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, Md.
Cathy Conry-CantilenaDepartment of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, Md.
Ervand KristosturyanLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, Md.
Harvey G KleinDepartment of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, Md.
Thomas A FleisherImmunology Service, Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, Md.
Steven M HollandLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, Md.
Harry L MalechLaboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Md.
Sergio D RosenzweigImmunology Service, Department of Laboratory Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, Md; Primary Immunodeficiency Clinic, NIAID, National Institutes of Health, Bethesda, Md. Electronic address: srosenzweig@cc.nih.gov.
National Institutes of Health · USNational Institutes of Health Clinical Center · US

Funding

Studies of Inherited Causes of Fungal SusceptabilityZIAAI001122 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ROSENZWEIG, SERGIO · 2010 to 2025
$26.0M
Gene Therapy Basic Research to Treat Inherited Primary Immune DeficienciesZIAAI000644 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MALECH, HARRY L · 2009 to 2025
$12.1M
Basic Research on Hematopoietic Human Stem CellsZIAAI000988 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MALECH, HARRY L · 2009 to 2019
$6.5M
Gene Therapy Clinical Trials for Chronic Granulomatous DiseaseZIAAI000991 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KANG, ELIZABETH · 2009 to 2019
$3.4M
Mutation Analysis Of Selected Lymphoid Immune DisordersZIACL010304 · CLC · CLINICAL CENTER · PI ROSENZWEIG, SERGIO · 2009 to 2025
$0k
Intramural NIH HHS Z99 CL999999
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Leukocyte TransfusionGranulocytesGranulomatous Disease, ChronicHumansInfectionsTreatment Outcome

Identifiers

PMID28342916
PMCPMC5546986
OpenAlexW2598739998

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.