ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2017
Steeper Slope of Age-Related Changes in White Matter Microstructure and Processing Speed in Bipolar Disorder.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- White Matter Microstructure in Individuals With and At Risk for Bipolar Disorder: Evidence for an Endophenotype From a Voxel-Based Meta-analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Pooled it
- State-Specific Segmental Abnormalities of White Matter Structure and Function in Pediatric Bipolar Disorders.Bipolar disorders · 2026Article
- Brain White Matter Microstructure in Middle and Older Aged Adults With Bipolar Disorder: A 2-Site Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Neurodegenerative model of schizophrenia: Growing evidence to support a revisit.Schizophrenia research · 2022Review
- Age moderates the relationship between affective response inhibition and bipolar disorder in adults.Journal of affective disorders · 2021Article
- White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis.Molecular psychiatry · 2021Article
- Age-related white matter changes revealed by a whole-brain fiber-tracking method in bipolar disorder compared to major depressive disorder and healthy controls.Psychiatry and clinical neurosciences · 2021Article
- Links between objective sleep and sleep variability measures and inflammatory markers in adults with bipolar disorder.Journal of psychiatric research · 2021Article
- White Matter Microstructure in Pediatric Bipolar Disorder and Disruptive Mood Dysregulation Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Article
- Decelerated epigenetic aging associated with mood stabilizers in the blood of patients with bipolar disorder.Translational psychiatry · 2020Article
- White matter microstructure in youth with and at risk for bipolar disorder.Bipolar disorders · 2020Article
- Examination and Comparison of Cognitive and Executive Functions in Clinically Stable Schizophrenia Disorder, Bipolar Disorder, and Major Depressive Disorder.Depression research and treatment · 2020Article
- Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder.BMC psychiatry · 2018Article
- Accelerated epigenetic aging and mitochondrial DNA copy number in bipolar disorder.Translational psychiatry · 2017Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesBipolar disorder (BD) is associated with compromised white matter (WM) integrity and deficits in processing speed (PS). Few studies, however, have investigated age relationships with WM structure and cognition to understand possible changes in brain health over the lifespan. This investigation explored whether BD and healthy counterpart (HC) participants exhibited differential age-related associations with WM and cognition, which may be suggestive of accelerated brain and cognitive aging.
designCross-sectional study.
settingUniversity of California San Diego and the Veterans Administration San Diego Healthcare System.
participants33 euthymic BD and 38 HC participants. MEASUREMENTS: Diffusion tensor imaging was acquired as a measure of WM integrity, and tract-specific fractional anisotropy (FA) was extracted utilizing the Johns Hopkins University probability atlas. PS was assessed with the Number and Letter Sequencing conditions of the Delis-Kaplan Executive Function System Trail Making Test.
resultsBD participants demonstrated slower PS compared with the HC group, but no group differences were found in FA across tracts. Multiple linear regressions revealed a significant group-by-age interaction for the right uncinate fasciculus, the left hippocampal portion of the cingulum, and for PS, such that older age was associated with lower FA values and slower PS in the BD group only. The relationship between age and PS did not significantly change after accounting for uncinate FA, suggesting that the observed age associations occur independently.
conclusionsResults provide support for future study of the accelerated aging hypothesis by identifying markers of brain health that demonstrate a differential age association in BD.
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