Evidence map›Paper›PMID 28342268›Full record

ArticleImmunology2017

The susceptible HLA class II alleles and their presenting epitope(s) in Goodpasture's disease.

Li-Jun Xie, Zhao Cui, Fang-Jin Chen, Zhi-Yong Pei, Shui-Yi Hu, Qiu-Hua Gu, Xiao-Yu Jia, Li Zhu, Xu-Jie Zhou, Hong Zhang and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Perlecan is a novel target of autoantibodies in anti-glomerular basement membrane disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  2. Article
  3. An overview of HLA variants in COVID-19 vaccine-induced autoimmunity.International journal of molecular epidemiology and genetics · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Experimental Antiglomerular Basement Membrane GN Induced by a Peptide fromJournal of the American Society of Nephrology : JASN · 2020
    Article
  8. Review
  9. Article
  10. Goodpasture's autoimmune disease - A collagen IV disorder.Matrix biology : journal of the International Society for Matrix Biology · 2018
    Review
  11. Review
  12. Collagen IVThe Journal of biological chemistry
    Article
  13. Collagen IVThe Journal of biological chemistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Li-Jun XieRenal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.ORCID 0000-0002-3973-0516
Zhao CuiRenal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.
Fang-Jin ChenState Key Laboratory for Structural Chemistry of Unstable and Stable Species, BNLMS, College of Chemistry and Molecular Engineering and Center for Theoretical Biology, Peking University, Beijing, China.
Zhi-Yong PeiBeijing Computing Center, Beijing, China.
Shui-Yi HuRenal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.
Qiu-Hua GuRenal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.ORCID 0000-0002-3389-5950
Xiao-Yu JiaRenal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.
Li ZhuRenal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.
Xu-Jie ZhouRenal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.
Hong ZhangRenal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.
Yun-Hua LiaoRenal Division, Department of Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Lu-Hua LaiState Key Laboratory for Structural Chemistry of Unstable and Stable Species, BNLMS, College of Chemistry and Molecular Engineering and Center for Theoretical Biology, Peking University, Beijing, China.
Billy G HudsonDepartment of Biochemistry, Division of Nephrology and Hypertention, Department of Medicine, Center for Matrix Biology, Aspirnaut Program, Department of Pathology, Microbiology, and Immunology, Department of Cell and Developmental Biology, Vanderbilt Ingram Cancer Centger, Vanderbilt Imstitute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
Ming-Hui ZhaoRenal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China.
Peking University · CNGuangxi Medical University · CNBeijing Computing Center · CNVanderbilt University · US

Funding

STUDIES ON THE STRUCTURE OF BASEMENT MEMBRANESR01DK018381 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Sergey Petrovich Budko, BILLY GERALD HUDSON · 1986 to 2026
$12.4M
NIDDK NIH HHS R01 DK018381
6 · The paper itself

Abstract

Goodpasture's disease is closely associated with HLA, particularly DRB1*1501. Other susceptible or protective HLA alleles are not clearly elucidated. The presentation models of epitopes by susceptible HLA alleles are also unclear. We genotyped 140 Chinese patients and 599 controls for four-digit HLA II genes, and extracted the encoding sequences from the IMGT/HLA database. T-cell epitopes of α3(IV)NC1 were predicted and the structures of DR molecule-peptide-T-cell receptor were constructed. We confirmed DRB1*1501 (OR = 4·6, P = 5·7 × 10

Indexed as

AllelesAnti-Glomerular Basement Membrane DiseaseAutoantigensChinaCollagen Type IVComputer SimulationEpitope MappingEpitopes, T-LymphocyteGenetic Predisposition to DiseaseGenotypeHLA-DRB1 ChainsHumansPolymorphism, GeneticProtein BindingProtein ConformationReceptors, Antigen, T-CellAutoantigensCollagen Type IVEpitopes, T-LymphocyteHLA-DRB1*15:01 antigenHLA-DRB1 ChainsReceptors, Antigen, T-Celltype IV collagen alpha3 chainanti- glomerular basement membrane diseaseepitopeGoodpasture's diseaseHLAMHC

Identifiers

PMID28342268
PMCPMC5506429
OpenAlexW2600864080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.