ArticleIntensive care medicine experimental2017
Granulocyte and monocyte adsorptive apheresis ameliorates sepsis in rats.
Article in Intensive care medicine experimental, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- The Efficacy of Whole Blood Exchange-Lymphoplasmapheresis Combined with Transfusion in Sepsis with Anemia.Shock (Augusta, Ga.) · 2026Article
- Granulocyte and monocyte adsorption therapy in sepsis: a propensity score-matched analysis.Journal of intensive care · 2026Article
- Reversal of ACLF and ALF using whole blood extracorporeal system combining HLA-depleted liver organoids with granulocyte-monocyte apheresis.Journal of hepatology · 2026Article
- Granulomonocytapheresis for chronic inflammatory diseases and sepsis.Journal of intensive care · 2025Review
- Acoustofluidic-based therapeutic apheresis system.Nature communications · 2024Article
- The Techniques of Blood Purification in the Treatment of Sepsis and Other Hyperinflammatory Conditions.Journal of clinical medicine · 2023Review
- Targeting Cytokines, Pathogen-Associated Molecular Patterns, and Damage-Associated Molecular Patterns in Sepsis via Blood Purification.International journal of molecular sciences · 2021Review
- Blood purification for sepsis: an overview.Precision clinical medicine · 2021Review
- Plasmacytoid dendritic cells promote acute kidney injury by producing interferon-α.Cellular & molecular immunology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOverwhelming activation of granulocytes and monocytes is central to inflammatory responses during sepsis. Granulocyte and monocyte adsorptive apheresis (GMA) is an extracorporeal leukocyte apheresis device filled with cellulose acetate beads and selectively adsorbs granulocytes and monocytes from the peripheral blood.
methodsIn this study, septic rats received the GMA treatment for 2 h at 18 h after cecal ligation and puncture.
resultsGMA selectively adsorbed activated neutrophils and monocytes from the peripheral blood, reduced serum inflammatory cytokine expression, and seemed to improve organ injuries and animal survival. GMA potentially reduced lung injury by alleviating the infiltration of inflammatory cells and the secretion of cytokines.
conclusionsThis study showed that selective granulocyte and monocyte adsorption with cellulose acetate beads might ameliorate cecal ligation and puncture (CLP)-induced sepsis and improve survival and organ function.
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Registered trials
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